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Merck
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N5536

Sigma-Aldrich

Nefazodone hydrochloride

≥98% (HPLC), solid, antidepressant

别名:

2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-5-ethyl- 2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride, BMY-13754, MJ-13754-1, Serzone

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About This Item

经验公式（希尔记法）:
C25H32ClN5O2 · HCl
CAS号:
82752-99-6
分子量:
506.47
MDL號碼:
MFCD00935760
分類程式碼代碼:
12352200
PubChem物質ID:
24724551
NACRES:
NA.77

产品名称

Nefazodone hydrochloride, ≥98% (HPLC), solid

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

儲存條件

desiccated

顏色

white

溶解度

DMSO: ≥10 mg/mL
H2O: insoluble

起源

Bristol-Myers Squibb

SMILES 字串

O=C1N(CCCN2CCN(C3=CC=CC(Cl)=C3)CC2)N=C(CC)N1CCOC4=CC=CC=C4.Cl

InChI

1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H

InChI 密鑰

DYCKFEBIOUQECE-UHFFFAOYSA-N

基因資訊

human ... HTR2A(3356) , HTR2C(3358) , SLC6A2(6530) , SLC6A4(6532)

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生化／生理作用

Novel antidepressant; mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor.

特點和優勢

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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分析证书(COA)

Lot/Batch Number
083M4732V
091M4724V
090M4745
068K4713
038K4733

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Jonathan N Bauman et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(6), 1016-1029 (2008-03-12)
In vitro metabolism/bioactivation of structurally related central nervous system agents nefazodone (hepatotoxin) and aripiprazole (nonhepatotoxin) were undertaken in human liver microsomes in an attempt to understand the differences in toxicological profile. NADPH-supplemented microsomal incubations of nefazodone and glutathione generated conjugates
Laura A Bajor et al.
Harvard review of psychiatry, 19(5), 240-258 (2011-09-16)
This project aimed to provide an organized, sequential, and evidence-supported approach to the pharmacotherapy of posttraumatic stress disorder (PTSD), following the format of previous efforts of the Psychopharmacology Algorithm Project at the Harvard South Shore Program. A comprehensive literature review
Rachel Manber et al.
Journal of consulting and clinical psychology, 76(3), 459-467 (2008-06-11)
The main aim of the present novel reanalysis of archival data was to compare the time to remission during 12 weeks of treatment of chronic depression following antidepressant medication (n = 218), psychotherapy (n = 216), and their combination (n
Ahmed Elkashef et al.
Substance abuse, 29(3), 17-29 (2008-12-02)
Marijuana is the number one illicit drug of abuse worldwide and a major public health problem, especially in the younger population. The objective of this article is to update and review the state of the science and treatments available for
Michael J Constantino et al.
Journal of consulting and clinical psychology, 80(3), 354-364 (2012-05-02)
Interpersonal theories posit that chronically depressed individuals have hostile and submissive styles in their social interactions, which may undermine their interpersonal effectiveness and maintain their depression. Recent findings support this theory and also show that patients' interpersonal impact messages, as
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