MAK305

CETP RP活性检测

(Supplied by Roar Biomedical, Inc.)

• 分類程式碼代碼: 12161503
• NACRES: NA.84

属性

• 用途: sufficient for 100 fluorometric tests
• 應用: pharmaceutical
• 檢測方法: fluorometric
• 相關疾病: cardiovascular diseases
• 儲存溫度: 2-8°C

说明

一般說明

Cholesteryl ester transfer protein (CETP) is present in normal human plasma and transfers neutral lipids from high density lipoproteins (HDL) to very low density lipoprotein (VLDL) and low density lipoprotein (LDL). CETP plays an important role in lipoprotein metabolism and influences the reverse cholesterol transport pathway.

特點和優勢

Synthetic assay components support manipulation for MOA studies and SAR work. Unusually high signal-to-background with linearity. Assay components stable for up to 1 year. High DMSO tolerance.

適合性

Suitable for high-throughput screening (HTS), mechanism of action (MOA) studies, and structure-activity relationship (SAR) work in CETP sources.

原則

The CETP RP Activity Assay uses a proprietary substrate that enables the detection of CETP-mediated neutral lipid mass transfer. The method is useful for measuring CETP activity in recombinant protein (RP) or purified CETP samples and has a high DMSO tolerance. The transfer activity results in an increase in fluorescence intensity (λ_Ex = 465 nm/λ_Em = 535 nm). With recombinant CETP as the CETP source, the assay is linear over a wide range of CETP concentrations and provides very high signal-to-background values. Typical Z factor: ∼0.9

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable