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About This Item
经验公式（希尔记法）:
C10H8N2O2S
CAS号:
分子量:
220.25
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
red to orange
溶解度
DMSO: >10 mg/mL
儲存溫度
2-8°C
SMILES 字串
NC1=NC(=O)C(\S1)=C\c2ccc(O)cc2
InChI
1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-
InChI 密鑰
YBHQCJILTOVLHD-YVMONPNESA-N
基因資訊
human ... MRE11A(4361)
應用
Mirin已被用作：
- 在辐照前的HCT116野生型细胞预处理中，用作减数分裂重组11（MRE11）的小分子抑制剂
- 作为感染猿猴病毒40的BSC-1细胞的Mre11抑制剂
- 在W12E细胞的预处理中，用于定量人乳头瘤病毒（HPV）附加体水平以及增强聚酰胺-25（PA-25）的作用
生化／生理作用
Mirin可导致细胞周期阻滞在G1期。 Mirin可增强病毒对抗病毒聚酰胺（AVP）的敏感性。在人乳头瘤病毒（HPV）附加体中，mirin通过形成双链DNA断裂来促进损伤作用。它有助于降低AVP的抑制浓度（IC50）。
Mirin是Mre11-Rad50-Nbs1复合物的抑制剂。它能够破坏Mre11的核酸酶活性，从而破坏DNA双链断裂修复能力。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
J-Y Wang et al.
Oncogene, 35(13), 1657-1670 (2015-06-23)
DNA repair is critical for the maintenance of genome stability. Upon genotoxic stress, dysregulated DNA repair may induce apoptosis. Translin-associated factor X (TRAX), which was initially identified as a binding partner of Translin, has been implicated in genome stability. However
Antiviral activity of pyrrole-imidazole polyamides against SV40 and BK polyomaviruses
Edwards TG and Fisher C
Antiviral Research, 152(4), 68-75 (2018)
AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11
Piscitello D, et al.
Oncogene, 37(4), 427-427 (2018)
DNA damage repair genes controlling human papillomavirus (HPV) episome levels under conditions of stability and extreme instability
Edwards TG, et al.
PLoS ONE, 8(10), e75406-e75406 (2013)
M Petroni et al.
Cell death and differentiation, 23(2), 197-206 (2015-06-13)
The MRE11/RAD50/NBS1 (MRN) complex is a major sensor of DNA double strand breaks, whose role in controlling faithful DNA replication and preventing replication stress is also emerging. Inactivation of the MRN complex invariably leads to developmental and/or degenerative neuronal defects
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