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M3445

Sigma-Aldrich

厚朴酚

≥90% (HPLC), from plant

别名:

2,2'-双香豆素, 5,5′-Diallyl-2,2′-biphenyldiol

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About This Item

经验公式（希尔记法）:
C18H18O2
CAS号:
528-43-8
分子量:
266.33
MDL號碼:
MFCD00016658
分類程式碼代碼:
12352100
PubChem物質ID:
24896843
NACRES:
NA.25

生物源

plant

化驗

≥90% (HPLC)

溶解度

ethanol: soluble 1 mg/mL
methanol: soluble 1.5 mg/mL

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria
fungi

應用

metabolomics
vitamins, nutraceuticals, and natural products

作用方式

cell membrane | interferes

儲存溫度

2-8°C

SMILES 字串

Oc1ccc(CC=C)cc1-c2cc(CC=C)ccc2O

InChI

1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2

InChI 密鑰

VVOAZFWZEDHOOU-UHFFFAOYSA-N

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相关类别

一般說明

厚朴酚是从不同中草药厚朴的根和茎皮中提取的一种具有生物活性的新木质素。它具有羟基化的双酚结构，类似于其结构异构体厚朴酚。它是一种亲脂化合物。

應用

厚朴酚已被用于：
  • 检测其对肌少症小鼠肌肉萎缩及巨噬细胞亚型的影响
  • 在血管生成实验中检测其对人脐静脉内皮细胞(HUVEC)的抑制作用
  • 检测其对念珠菌生长、超微结构和生物膜形成的抑制作用
  • 制备固定化氨基功能化介孔二氧化硅颗粒，以进行缓释研究

生化／生理作用

厚朴酚具有抗抑郁和神经退行性。它还被认为是一种有效的抗癌药物，参与减少细胞增殖，细胞毒性和诱导细胞凋亡。
厚朴酚是从木兰科植物 厚朴的根和茎皮中分离得到的一种具有生物活性的植物成分 ，具有抗真菌、 抗菌 和抗氧化作用。厚朴酚还通过干扰 NF-κ 而显示抗炎活性 B 信号传导。由于其能够抑制 IL-6 诱导的 STAT3 活化，因此其似乎也具有与血管疾病（如动脉粥样硬化）相关的抗炎属性。

訊號詞

Danger

危險分類

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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Rajendra Karki et al.
Experimental cell research, 319(20), 3238-3250 (2013-08-03)
Increased proliferation and migration of vascular smooth muscle cells (VSMCs) contribute importantly to the formation of both atherosclerotic and restenotic lesions. The objective of this study was to investigate the effect of magnolol on VSMC migration. The proteolytic activity of
Abhishek Manoj Ranaware et al.
International journal of molecular sciences, 19(8) (2018-08-15)
The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will
Hanna Kuk et al.
Scientific reports, 7(1), 17820-17820 (2017-12-21)
Due to gravity the venous vasculature in the lower extremities is exposed to elevated pressure levels which may be amplified by obesity or pregnancy. As a consequence, venules dilate and may be slowly transformed into varicose or spider veins. In
Development of a prolonged-release drug delivery system with magnolol loaded in amino-functionalized mesoporous silica
Stefanache A, et al.,
Applied Sciences, 237-237 (2017)
Yong Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(23), 3526-3530 (2013-03-13)
Magnolol is one of main active constituents from Magnolia officinalis, a widely used traditional Chinese medicine. Previous studies have proved its multiple pharmacological effects, such as anti-oxidation, anti-microbial and anti-tumor. In recent years, more and more studies have focused on
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