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J4252

Sigma-Aldrich

JWH-015

≥98% (HPLC), powder

别名:

(2-Methyl-1-propyl-1H-indol-3-yl)-1-naphthalenylmethanone

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About This Item

经验公式（希尔记法）:
C23H21NO
CAS号:
155471-08-2
分子量:
327.42
MDL號碼:
MFCD02094630
分類程式碼代碼:
12352200
PubChem物質ID:
24278502
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

藥物控制

regulated under CDSA - not available from Sigma-Aldrich Canada

顏色

off-white

溶解度

DMSO: >20 mg/mL (with heating)

儲存溫度

−20°C

SMILES 字串

CCCn1c(C)c(C(=O)c2cccc3ccccc23)c4ccccc14

InChI

1S/C23H21NO/c1-3-15-24-16(2)22(20-12-6-7-14-21(20)24)23(25)19-13-8-10-17-9-4-5-11-18(17)19/h4-14H,3,15H2,1-2H3

InChI 密鑰

LJSBBBWQTLXQEN-UHFFFAOYSA-N

基因資訊

human ... CNR2(1269)
rat ... Cnr1(25248)

應用

JWH-015 has been used to study its effect on tumor-evoked pain behavior. It has also been used to study its protective effects on rat brain mitochondria upon paraquat exposure.

生化／生理作用

JWH-015 is a selective CB2 cannabinoid receptor agonist. JWH-015 is structurally classified as naphthoylindoles.

特點和優勢

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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分析证书(COA)

Lot/Batch Number
041M4613V
109K47062
109K47061
109K4706
018K4712

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Intrathecal Administration of the Cannabinoid 2 Receptor Agonist JWH015 Can Attenuate Cancer Pain and Decrease mRNA Expression of the 2B Subunit of N-Methyl-D-Aspartic Acid
XiaoPing G, et al.
Journal of Cell Science, jcs-100925 (2012)
Joseph E Henriquez et al.
Toxicology and applied pharmacology, 369, 82-89 (2019-02-27)
Plasmacytoid dendritic cells (pDC) compose 0.2-0.5% of circulating leukocytes but play a significant role in mounting host immune responses. Elevated and chronic activation of pDC are implicated in autoimmune disease like systemic lupus erythematosus and rheumatoid arthritis. Δ9-tetrahydrocannabinol (THC) is
Jinhong Liu et al.
Experimental and therapeutic medicine, 18(6), 4241-4248 (2019-11-30)
Inflammation serves an important role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Cannabinoid receptor 2 (CB2R) is a receptor predominantly expressed in the immune system. CB2R agonists can be used to treat a wide range of inflammation-related diseases. Pirfenidone
Sumana Ghosh et al.
Frontiers in cellular neuroscience, 12, 271-271 (2018-09-07)
Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these
Clinical Toxicology, An Issue of Emergency Medicine Clinics of North America, 4-4 (2014)
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