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化驗
≥98% (HPLC)
形狀
powder
顏色
off-white to light brown
溶解度
DMSO: ≥5 mg/mL
儲存溫度
2-8°C
SMILES 字串
C\C(C)=C\COc1c2OC(=O)C=Cc2cc3ccoc13
InChI
1S/C16H14O4/c1-10(2)5-7-19-16-14-12(6-8-18-14)9-11-3-4-13(17)20-15(11)16/h3-6,8-9H,7H2,1-2H3
InChI 密鑰
OLOOJGVNMBJLLR-UHFFFAOYSA-N
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生化／生理作用
Imperatorin is a modulator of p38, ERK pathway.
Imperatorin is a modulator of p38, ERK pathway. Imperatorin increases BMP-2 expression (mRNA) and increases bone density/volume and mineralization in vivo.
Imperatorin is an important bioactive furanocoumarin. It is used to treat neurodegenerative diseases. It possesses anticancer, antibacterial, anti-inflammatory and HIV replication-inhibiting activities. Imperatorin serves as an inhibitor of acetylcholinesterase (AChE) and may help in treating Alzheimer′s disease (AD) and Parkinson′s disease (PD).
特點和優勢
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Zhangqian Wang et al.
Pest management science, 68(7), 1041-1047 (2012-03-06)
An assessment was made of the toxicity of imperatorin and osthole identified in Cnidium monnieri fruit, 11 related compounds and five insecticides to larvae from insecticide-susceptible Culex pipiens pallens (KS-CP strain) and Aedes aegypti and wild C.p. pallens (YS-CP colony)
Guan-Jhong Huang et al.
Journal of agricultural and food chemistry, 60(7), 1673-1681 (2011-12-23)
In this study, we have investigated the anti-inflammatory effects of imperatorin, a compound isolated from the roots of Glehnia littoralis, using a lipopolysaccharide (LPS)-stimulated mouse macrophage (RAW264.7) in vitro and a carrageenan (Carr)-induced mouse paw edema model in vivo. When
Yan Zhang et al.
Fitoterapia, 83(1), 60-66 (2011-10-11)
Augmented endothelial nitric oxide (NO) synthase (eNOS) signaling has been reported to be associated with improvements in cardiac remodeling, and NO levels have been shown to be related to cardiac hypertrophy and heart failure. Imperatorin, a dietary furanocoumarin, has been
Jin Bae Weon et al.
Journal of natural medicines, 66(3), 510-515 (2012-02-24)
In this study, an effective high performance liquid chromatography-diode array detector (HPLC-DAD) method was established for simultaneous determination of six marker compounds, ephedrine hydrochloride, 6-gingerol, glycyrrhizin, hesperidin, imperatorin and ferulic acid, in a Korean traditional prescription, Oyaksungisan, which is used
Xia Lv et al.
Food chemistry, 138(4), 2260-2266 (2013-03-19)
Imperatorin (IMP) is a major constituent of many herbal medicines and possesses anti-osteoporosis activity. The present research work aimed to study the biotransformation processes of IMP and evaluated the anti-osteoporosis activity of the transformed metabolites. Among 18 strains of filamentous
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