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品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
off-white to light yellow
溶解度
DMSO: ≥5 mg/mL
儲存溫度
2-8°C
SMILES 字串
O=C(C1=CC([N+]([O-])=O)=CC=C1)NC2=NC3=C(N2CCN4CCOCC4)C=CC=C3
InChI
1S/C20H21N5O4/c26-19(15-4-3-5-16(14-15)25(27)28)22-20-21-17-6-1-2-7-18(17)24(20)9-8-23-10-12-29-13-11-23/h1-7,14H,8-13H2,(H,21,22,26)
InChI 密鑰
QTCFYQHZJIIHBS-UHFFFAOYSA-N
應用
IRAK-1/4抑制剂I已用于各种研究，用于抑制肝癌细胞系和头颈部鳞状细胞癌（HNSCC）细胞系中的IRAK1。
生化／生理作用
IRAK-1/4抑制剂I是一种新型苯并咪唑，且是白细胞介素-1受体相关激酶1/4（IRAK 1/4）的一种有效抑制剂。 对于IRAK-1和-4的IC50值分别为300 nM和200 nM，而对于测试的一组27种其他激酶，IC 50值> 10,000 nM。
IRAK1过度表达会导致头颈部鳞状细胞癌（HNSCC）的发展。因此，IRAK-1/4抑制剂I可能是HNSCC肿瘤的潜在治疗剂。各种实验研究表明，IRAK-1/4抑制剂可能对核因子(NF)-κB信号通路有抑制作用。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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