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Merck

I4625

Sigma-Aldrich

肌苷-5′-单磷酸 二钠盐 水合物

from yeast, Grade III, ≥98% (HPLC)

别名:

5 & # 8242;-肌苷酸 二钠盐 水合物, 5′-IMP-Na2, I-5′-P, IMP, 肌苷酸

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About This Item

经验公式(希尔记法):
C10H11N4O8PNa2 · xH2O
分子量:
392.17 (anhydrous basis)
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

生物源

yeast

品質等級

種類

Grade III

化驗

≥98% (HPLC)

形狀

powder

溶解度

water: 50 mg/mL, clear, colorless

儲存溫度

2-8°C

SMILES 字串

[Na+].[Na+].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])([O-])=O)n2cnc3C(=O)NC=Nc23

InChI

1S/C10H13N4O8P.2Na.H2O/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;;/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI 密鑰

KQCIGEIXDXQSGM-MSQVLRTGSA-L

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應用

5′-肌苷单磷酸二钠盐水合物已用于:
  • 作为鸡味觉阈值检测中的5′-核糖核苷酸类味质化合物
  • 制作高效液相色谱(HPLC)标准曲线以定量分析虾尾组织样本中的IMP
  • 作为McCoy′s 5A完全培养基组分,用于培养间日疟原虫Plasmodium vivax

肌苷-5′-单磷酸(IMP)被作为底物用于研究肌苷-5′-单磷酸脱氢酶(IMPDH)的分布、特异性和动力学。

生化/生理作用

5′-肌苷单磷酸(肌苷酸,IMP)是一种膳食核苷酸,由真核细胞中的腺苷单磷酸(AMP)合成。它是一种食品添加剂,对于肠道健康和免疫至关重要。
肌苷一磷酸或肌苷酸是次黄嘌呤的核糖核苷酸,是嘌呤合成过程中形成的第一个核苷酸。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Shubo Li et al.
Food chemistry, 216, 275-281 (2016-09-07)
5'-adenylic acid deaminase (AMP deaminase), an important enzyme for the food industry, can catalyze the irreversible hydrolysis of adenosine monophosphate (AMP) to inosine monophosphate (IMP) and ammonia. In this study, a new strain was screened that efficiently produces 3191.6U/g of
Effect of salt treatments on survival and consumer acceptability of freshwater prawn, Macrobranchium rosenbergii
Ciaramella MA, et al.
Aquaculture (Amsterdam, Netherlands), 428 (428)
Shira L Cheled-Shoval et al.
Poultry science, 96(7), 2206-2218 (2017-03-25)
The sense of taste has a key role in nutrient sensing and food intake in animals. A standardized and simple method for determination of tastant-detection thresholds is required for chemosensory research in poultry. We established a 24-h, 2-alternative, forced-choice solution-consumption
Helen R Josephine et al.
Biochemistry, 49(50), 10674-10681 (2010-11-11)
X-ray crystal structures of enzyme-ligand complexes are widely believed to mimic states in the catalytic cycle, but this presumption has seldom been carefully scrutinized. In the case of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase (IMPDH), 10 structures of various enzyme-substrate-inhibitor complexes
Bjarne G Hansen et al.
BMC microbiology, 11, 202-202 (2011-09-20)
Many secondary metabolites produced by filamentous fungi have potent biological activities, to which the producer organism must be resistant. An example of pharmaceutical interest is mycophenolic acid (MPA), an immunosuppressant molecule produced by several Penicillium species. The target of MPA

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Neoplastic cells are highly dependent on the de novo synthesis of nucleotides to maintain sufficient pools to support DNA replication and the production of RNA.

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