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生物源
goat
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
secondary antibodies
無性繁殖
polyclonal
形狀
lyophilized powder
技術
Ouchterlony double diffusion: suitable
儲存溫度
2-8°C
目標翻譯後修改
unmodified
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一般說明
IgG抗体亚型是免疫系统中含量最高的血清免疫球蛋白。它由B细胞分泌，存在于血液和细胞外液中，可防止细菌、真菌和病毒引起的感染。母体IgG通过胎盘传递至胎儿，对新生儿的感染免疫防御能力至关重要。人IgG（γ链特异性）抗体对所有人IgG亚类的γ链具有特异性。
免疫球蛋白（Ig）属于免疫球蛋白超家族，包含两条重链（H）和两条轻链（L），它们通过二硫键相连。L链包含一个可变N-末端区域和一个恒定C-末端区域。重链包有一个N-端可变区和三个或四个（CH1-CH4）C-端恒定区。IgG是人血清中含量最丰富的一种蛋白。IgG分为IgG1、IgG2、IgG3和IgG4四类。IgG重链区域定位于人类14号染色体。
免疫原
纯化人IgG
應用
人IgG（γ链特异性）抗体在ELISA和放射免疫分析中可作为对照品使用。
生化／生理作用
IgG1类是最丰富的，其缺乏会导致低丙球蛋白血症。IgG2缺乏会增加对细菌感染的易感性。IgG3介导效应子功能，IgG4与无症状感染有关。木瓜蛋白酶消化IgG导致产生片段抗原结合（Fab）。IgG的胃蛋白酶消化形成可结晶的片段（Fc）。IgG抗体的Fc区具有巨大的治疗潜力，可用于开发治疗性抗体。
外觀
0.01 mM 磷酸钠，0.015 mM 氯化钠，pH 7.2
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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Chinese hamster ovary (CHO) cells are the most commonly used mammalian hosts for the production of biopharmaceuticals. To overcome unfavorable features of CHO cells, a lot of effort is put into cell engineering to improve phenotype. "Omics" studies investigating elevated
R J Cox et al.
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The radio-immunoblot (RIB) assay was used to examine the antibody response to proteins of the vaccine strains induced after influenza vaccination. Vaccination stimulated an antibody response to the surface glycoproteins (HA and NA) and to the internal antigens (NP and
Andreas Maccani et al.
Applied microbiology and biotechnology, 98(17), 7535-7548 (2014-07-24)
MicroRNAs are short non-coding RNAs that play an important role in the regulation of gene expression. Hence, microRNAs are considered as potential targets for engineering of Chinese hamster ovary (CHO) cells to improve recombinant protein production. Here, we analyzed and
V L Esnault et al.
Immunology, 74(4), 714-718 (1991-12-01)
Circulating IgG autoantibodies to myeloperoxidase (MPO) are associated with renal vasculitis and have been implicated in its pathogenesis. However, raised levels of these autoantibodies may persist during clinical remission. We tested whether this paradox could be explained by immunoglobulin subclass
商品
Antibody-based serology tests are useful in identifying subjects with an adaptive immune response to the SARS-CoV-2 virus. Anti-human immunoglobulin antibodies allow for quick and simple, yet reliable assays with easy readouts and can also be adapted for high-throughput screening.
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