HPA023890
Anti-CMTM4 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
别名:
Anti-CKLF-like MARVEL transmembrane domain-containing protein 4, Anti-Chemokine-like factor superfamily member 4
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About This Item
推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
加強驗證
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
技術
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:20-1:50
免疫原序列
GEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYL
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CMTM4(146223)
相关类别
一般說明
CKLF (chemokine-like factor) like MARVEL transmembrane domain containing 4 (CMTM4) belongs to the CKLF like MARVEL transmembrane domain containing family (CMTM). The gene is located on human chromosome 16q21-q22.1. It is highly expressed in kidney, heart and brain.
免疫原
CKLF-like MARVEL transmembrane domain-containing protein 4 recombinant protein epitope signature tag (PrEST)
應用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
生化／生理作用
CKLF (chemokine-like factor) like MARVEL transmembrane domain containing 4 (CMTM4) functions as a regulator of cell cycle and division in HeLa cells. It acts as a tumor suppressor in clear cell renal cell carcinoma, when downregulated. The protein is involved in cell cycle growth. It regulates the protein programmed death-ligand 1 (PD-L1). It acts a target for microRNA-205 and enhances renal cell apoptosis.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST73177
外觀
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
MicroRNA-205 inhibits renal cells apoptosis via targeting CMTM4
Zhang H, et al.
Iranian Journal of Basic Medical Sciences, 18(10), 1020-1020 (2015)
CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma
Li T, et al.
Journal of Experimental & Clinical Cancer Research, 34(1), 122-122 (2015)
Identification of CMTM6 and CMTM4 as PD-L1 protein regulators
Mezzadra R, et al.
Nature, 549(7670), 106-106 (2017)
Integrated analysis of copy number and loss of heterozygosity in primary breast carcinomas using high-density SNP array
Ching HC, et al.
International Journal of Oncology, 39(3), 621-633 (2011)
Markus Plate et al.
Molecules and cells, 29(4), 355-361 (2010-03-10)
Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only
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