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應用
组蛋白适用于：
- 作为体外激酶测定的阳性对照，检测Cdc2-细胞周期蛋白B1磷酸化GST-CD-4蛋白的能力
- Cdk5活性测定
- 组蛋白H1激酶测定
- 作为聚ADP-核糖(PAR)受体，检测体外PAR聚合酶活性
- 作为[γ-32P]ATP来源32P的受体，检测小、大黄体细胞来源裂解液的蛋白激酶活性
生化／生理作用
组蛋白是一组DNA结合蛋白，其特征是赖氨酸和精氨酸含量较高。组蛋白的分子量在11-21 kDa之间，取决于具体级分。分离和表征了五种不同的组蛋白级分。H1富含赖氨酸、H2a和H2b略微富含赖氨酸、H3和H4富含精氨酸。H1用于连接染色质链上的各个“念珠”(nu bodies)。
特點和優勢
不要将Sigma“类型”名称与Luck及其同事使用的“分级”名称混淆。
其他說明
经SDS-PAGE鉴定，主要为f1亚型
準備報告
富含赖氨酸的级分，分离和描述依据文献（de Nooij, E. and Westenbrink, H.G., BiochimBiophys.Acta, 62, 608 (1962)）。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Q P Dou et al.
Cancer research, 53(7), 1493-1497 (1993-04-01)
Progression of cells into S phase is proposed to be determined by accumulation of a labile protein (the restriction point protein R; A. B. Pardee, Proc. Natl. Acad. Sci. USA, 71: 1286-1290, 1974). We report here that cyclin E and
Scott T
Concise encyclopedia of biochemistry, 265-265 (1988)
Amit K Dutta et al.
Journal of colloid and interface science, 324(1-2), 55-60 (2008-05-30)
The real-time changes in viscoelasticity of adsorbed poly(L-lysine) (PLL) and adsorbed histone (lysine rich fraction) due to cross-linking by glutaraldehyde and corresponding release of associated water were investigated using a quartz crystal microbalance with dissipation monitoring (QCM-D) and attenuated total
Mária Čížková et al.
Cells, 8(7) (2019-07-20)
DNA damage is a ubiquitous threat endangering DNA integrity in all living organisms. Responses to DNA damage include, among others, induction of DNA repair and blocking of cell cycle progression in order to prevent transmission of damaged DNA to daughter
Wei-Li Zhu et al.
The international journal of neuropsychopharmacology, 15(6), 795-809 (2011-06-21)
Depression is one of the most pervasive and debilitating psychiatric diseases, and the molecular mechanisms underlying the pathophysiology of depression have not been elucidated. Cyclin-dependent kinase 5 (Cdk5) has been implicated in synaptic plasticity underlying learning, memory, and neuropsychiatric disorders.
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