所有图片(1)
About This Item
经验公式（希尔记法）:
C35H52O4
CAS号:
分子量:
536.78
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
品質等級
化驗
≥85% (HPLC)
形狀
solution
儲存溫度
−20°C
SMILES 字串
CC(C)C(=O)[C@@]12C(O)=C(C\C=C(\C)C)C(=O)[C@@](C\C=C(/C)C)(C[C@H](C\C=C(\C)C)[C@@]1(C)CC\C=C(\C)C)C2=O
InChI
1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1
InChI 密鑰
IWBJJCOKGLUQIZ-HQKKAZOISA-N
一般說明
贯叶金丝桃素是圣约翰′草的一种间苯三酚成分，同时也是一种孕烷 X 受体配体。
應用
贯叶金丝桃素可用于：
- 作为参考标准品用于制定高效液相色谱 (HPLC) 分析的校准曲线
- 测试其对小鼠他胚胎细胞的细胞毒性作用和诱导细胞凋亡作用
- 作为猪脑毛细血管内皮细胞孕烷X受体 (PXR) 用于传递检测
生化／生理作用
贯叶金丝桃素是一种活性抗抑郁剂和细胞色素P450 3A4 (CYP3A) 抑制剂。它可诱导抗氧化和抗细菌活性。贯叶金丝桃素还具有胚胎毒性并抑制肿瘤增生。它可有效抑制多巴胺、血清素和去甲肾上腺素。
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
標靶器官
Eyes
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
49.5 °F - closed cup
閃點（°C）
9.7 °C - closed cup
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
T N Griffith et al.
Current medicinal chemistry, 17(5), 391-406 (2009-12-18)
St. John's Wort (SJW) has been used medicinally for over 5,000 years. Relatively recently, one of its phloroglucinol derivatives, hyperforin, has emerged as a compound of interest. Hyperforin first gained attention as the constituent of SJW responsible for its antidepressant
Mechanisms controlling neurite outgrowth in a pheochromocytoma cell line: the role of TRPC channels.
Sanjay Kumar et al.
Journal of cellular physiology, 227(4), 1408-1419 (2011-05-28)
Transient Receptor Potential Canonical (TRPC) channels are implicated in modulating neurite outgrowth. The expression pattern of TRPCs changes significantly during brain development, suggesting that fine-tuning TRPC expression may be important for orchestrating neuritogenesis. To study how alterations in the TRPC
Martina C Meinke et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(2), 346-350 (2012-03-21)
Hyperforin, a major constituent of St. John's Wort (Hypericum perforatum, HP), provides anti-inflammatory, anti-tumor, and anti-bacterial properties. Previous studies have shown anti-oxidative properties of St. John's Wort extracts; however, its free radical scavenging activity in skin cells or skin has
Rajanikanth Madabushi et al.
European journal of clinical pharmacology, 62(3), 225-233 (2006-02-16)
Recently, interactions of herbal medicines with synthetic drugs came into focus of particular interest. In the past 3 years, more than 50 papers were published regarding interactions between St. John's wort (Hypericum perforatum L.; SJW) and prescription drugs. Co-medication with
Jeffry Adiwidjaja et al.
Clinical pharmacokinetics, 58(7), 911-926 (2019-01-25)
Herb-drug interactions with St John's wort (SJW) have been widely studied in numerous clinical studies. The objective of this study was to develop and evaluate a physiologically based pharmacokinetic (PBPK) model for hyperforin (the constituent of SJW responsible for interactions)
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