H140
(R)-(+)-8-Hydroxy-DPAT hydrobromide
≥98% (HPLC), solid
别名:
(R)-(+)-2-Dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide, (R)-(+)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide
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所有图片(1)
About This Item
经验公式（希尔记法）:
C16H25NO · HBr
CAS号:
分子量:
328.29
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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化驗
≥98% (HPLC)
形狀
solid
光學活性
[α]25/D +68.2°, c = 1 in methanol(lit.)
儲存條件
desiccated
protect from light
顏色
white to off-white
溶解度
H2O: >10 mg/mL at ±60 °C (with sonication)
SMILES 字串
Br.CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1
InChI
1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m1./s1
InChI 密鑰
BATPBOZTBNNDLN-PFEQFJNWSA-N
基因資訊
human ... HTR1A(3350)
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應用
(R)-(+)-8-Hydroxy-DPAT hydrobromide has been used as a 5-HT1A agonist:
- in mice to test the activity of the serotonin receptor
- to test its effect on zebrafish melanocyte migration and survival
- to stimulate hippocampal neurons
生化／生理作用
(R)-(+)-8-Hydroxy-DPAT administration reduces aggressive behavior. It decreases food intake by modifying the sensitivity of 5-HT1A receptor during food deprivation.
(R)-(+)-8-Hydroxy-DPAT is a full 5-HT1A serotonin receptor agonist; active enantiomer of (±)-8-hydroxy-DPAT.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Masatoshi Nagano et al.
Scientific reports, 8(1), 13675-13675 (2018-09-14)
Disturbance of neurotransmitters and neuromodulators is thought to underlie the pathophysiology of autism spectrum disorder (ASD). Studies of 15q dup mouse models of ASD with human 15q11-13 duplication have revealed that restoring serotonin (5-HT) levels can partially reverse ASD-related symptoms
Mice do not habituate to metabolism cage housing-a three week study of male BALB/c mice
Kalliokoski O, et al.
PLoS ONE, 8(3), 1176-1185 (2013)
Jan Brosda et al.
ACS chemical neuroscience, 6(7), 1176-1185 (2015-03-18)
Brain serotonin (5-HT) is involved in the control of food intake. The ingestive effects of 5-HT are mediated by various receptor subtypes, among others the 5-HT1A receptor. While the involvement of presynaptic 5-HT1A receptors is regarded as certain, the role
Florence Razoux et al.
NeuroImage, 74, 326-336 (2013-03-05)
Imaging methods that enable the investigation of functional networks both in human and animal brain provide important insights into mechanisms underlying pathologies including psychiatric disorders. Since the serotonergic receptor 1A (5-HT(1A)-R) has been strongly implicated in the pathophysiology of depressive
L Björk et al.
Journal of medicinal chemistry, 32(4), 779-783 (1989-04-01)
The enantiomers of the N,N-dimethylamino (1), N,N-diethylamino (2), and N,N-dibutylamino (4) derivatives of 8-hydroxy-2-(dipropylamino)tetralin (8-OH DPAT; 3) have been synthesized. The compounds have been tested for activity at central 5-hydroxytryptamine and dopamine receptors by use of biochemical and behavioral tests
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