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生物源
chicken
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
human, mouse, rat
製造商／商標名
Genway 15-288-20008F
技術
indirect ELISA: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... A2M(2)
免疫原
α-2-Macroglobulin (validated) native human protein.
Immunogen Sequence: GI # 68765, sequence 1-1474
應用
Anti-α-2-Macroglobulin antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200. It is also used for indirect ELISA.
生化／生理作用
A2M (α-2-macroglobulin) inhibits all four classes of proteinases by a unique ′trapping′ mechanism. This protein undergoes a conformational change when a proteinase binds and cleaves a specific peptide stretch called the "bait region" in the protein. This modified protein traps the bound proteinase It is involved in the clearance and degradation of Aβ, which is a major component of beta-amyloid deposits. Therefore, it is associated with Alzheimer′s disease (AD).
外觀
Solution in phosphate buffered saline containing 0.02% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
S L Gonias et al.
Biochimica et biophysica acta, 705(3), 306-314 (1982-08-10)
Circular dichroism spectroscopy, sedimentation velocity and ultraviolet difference spectroscopy were used to compare alpha 2-macroglobulin, alpha 2-macroglobulin-trypsin complex and alpha 2-macroglobulin-methylamine complex. The circular dichroic spectrum of native alpha 2-macroglobulin is significantly changed in shape and magnitude following reaction with
M P Cuajungco et al.
Annals of the New York Academy of Sciences, 920, 292-304 (2001-02-24)
Alzheimer's disease is a rapidly worsening public health problem. The current lack of effective treatments for Alzheimer's disease makes it imperative to find new pharmacotherapies. At present, the treatment of symptoms includes use of acetylcholinesterase inhibitors, which enhance acetylcholine levels
M Hall et al.
FEBS letters, 254(1-2), 111-114 (1989-08-28)
Alpha 2-Macroglobulin (alpha 2 M) was isolated from plasma of the freshwater crayfish, Pacifastacus leniusculus, using ultracentrifugation, ion-exchange chromatography and gel filtration techniques. The Pacifastacus alpha 2 M molecule (P alpha 2 M) was radio-actively labeled in the thiol ester
X Huang et al.
The Journal of nutrition, 130(5S Suppl), 1488S-1492S (2000-05-10)
Alzheimer's disease (AD) is characterized by amyloid deposits within the neocortical parenchyma and the cerebrovasculature. The main component of these predominantly extracellular collections, Abeta, which is normally a soluble component of all biological fluids, is cleaved out of a ubiquitously
Vivian Lobo et al.
Molecular human reproduction, 25(3), 137-155 (2018-12-28)
Glucose regulated protein 78 (GRP78) is expressed on cell surface in exceptional conditions as seen in cancer cells and macrophages. We have reported its membrane localization in sperm. The functional significance of its surface localization in sperm is an enigma.
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