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Merck

G5660

Sigma-Aldrich

Lysoganglioside-GM1 from bovine brain

≥95%, lyophilized powder

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About This Item

MDL號碼:
分類程式碼代碼:
12352204

品質等級

化驗

≥95%

形狀

lyophilized powder

儲存溫度

−20°C

相关类别

生化/生理作用

Suggested to be a modulator of cell growth and signal transduction. Accumulates in the nervous system of patients with GM1 gangliosidosis. Used for the preparation of GM1 derivatives containing different fatty acids, fluorescent tags, or other residues.

其他說明

Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum; contain a sialated polysaccharide chain linked to ceramide through a β-glycosidic linkage; for classification of gangliosides see Svennerholm, L., et al. (eds.), Structure and Function of Gangliosides, New York, Plenum, 1980.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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A Kharlamov et al.
Proceedings of the National Academy of Sciences of the United States of America, 91(14), 6303-6307 (1994-07-05)
A bilateral photochemically induced thrombotic lesion of rat sensorimotor cortex (approximately 3 mm in diameter and 25 mm3 in volume) is associated with a persistent cognition (learning and memory) deficit, which was evaluated with water maze tasks. The N-dichloroacetylsphingosine derivative
Y A Hannun et al.
Science (New York, N.Y.), 235(4789), 670-674 (1987-02-06)
Lysosphingolipids potently and reversibly inhibited protein kinase C activity and binding of phorbol dibutyrate in vitro and in human platelets. As with activation of protein kinase C by phosphatidylserine and sn-1,2-diacylglycerol, inhibition was subject to surface dilution. Accordingly, inhibition in
T Kobayashi et al.
Journal of neurochemistry, 59(4), 1452-1458 (1992-10-01)
By using a sensitive method, we assayed lysocompounds of gangliosides and asialogangliosides in tissues from four patients with GM2 gangliosidosis (one with Sandhoff disease and three with Tay-Sachs disease) and from three patients with GM1 gangliosidosis [one with infantile type
Tubaro, E., et al.
Eur. J. Pharmacol. Environ. Toxicol. Pharmacol. Soc., 248, 175-175 (1993)
R T Huang et al.
FEBS letters, 281(1-2), 39-42 (1991-04-09)
Fluorescent dansyl derivatives of 3 natural sphingolipids (gangliosides, cerebroside and sphingomyelin) were shown to be readily taken up by culture cells (HeLa-, MDCK- and primary rat brain cells). A part of the incorporated fluorescent sphingolipids remained associated with the cells

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