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Merck

E8909

Sigma-Aldrich

Phosphodiesterase 3B

recombinant, expressed in Sf9 cells

别名:

3′,5′-cyclic-nucleotide phosphodiesterase, PDE 3B

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About This Item

MDL號碼:
分類程式碼代碼:
12352204
NACRES:
NA.54

重組細胞

expressed in Sf9 cells

品質等級

形狀

buffered aqueous solution

比活性

≥1000 units/μg protein

運輸包裝

dry ice

儲存溫度

−70°C

相关类别

應用

Phosphodiesterase 3B has been used in a study to evaluate the evidence for biological effects of metformin in operable breast cancer. Phosphodiesterase 3B has also been used in a study to investigate the role of intracellular and intercellular communication in perfusion distribution of erythrocyte-derived ATP.

物理性質

N-terminal GST-tagged 86 kDa protein containing amino acids 592-end

單位定義

One unit will convert 1.0 picomole of 3′,5′-cAMP to 5′-AMP per minute at pH 7.4 at 37 °C.

外觀

Buffered aqueous solution containing Tris-HCl (pH 8.0), NaCl, KCl, Tween-20, DTT, and glycerol

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Lin Xie et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 18(4), 444-454 (2011-12-14)
Here we examined whether the expression of a novel immunoregulatory gene set could be used to predict outcomes in murine models of rapamycin-induced cardiac tolerance, spontaneous hepatic tolerance, and cardiac rejection. The expression of the immunoregulatory gene set was assessed
Sirwan Hadad et al.
Breast cancer research and treatment, 128(3), 783-794 (2011-06-10)
Metformin may reduce the incidence of breast cancer and enhance response to neoadjuvant chemotherapy in diabetic women. This trial examined the effects of metformin on Ki67 and gene expression in primary breast cancer. Non-diabetic women with operable invasive breast cancer
Randy S Sprague et al.
Microcirculation (New York, N.Y. : 1994), 19(5), 430-439 (2012-07-11)
In complex organisms, both intracellular and intercellular communication are critical for the appropriate regulation of the distribution of perfusion to assure optimal O(2) delivery and organ function. The mobile erythrocyte is in a unique position in the circulation as it
The cyclic AMP pathway.
Paolo Sassone-Corsi
Cold Spring Harbor perspectives in biology, 4(12), doi:10-doi:10 (2012-12-05)
Koji Ochiai et al.
Bioorganic & medicinal chemistry letters, 23(1), 375-381 (2012-12-04)
(-)-6-(7-Methoxy-2-(trifluoromethyl)pyrazolo[1,5-a]pyridin-4-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-one (KCA-1490) exhibits moderate dual PDE3/4-inhibitory activity and promises as a combined bronchodilatory/anti-inflammatory agent. N-alkylation of the pyridazinone ring markedly enhances potency against PDE4 but suppresses PDE3 inhibition. Addition of a 6-aryl-4,5-dihydropyridazin-3(2H)-one extension to the N-alkyl group facilitates both enhancement

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