推荐产品
生物源
synthetic
無菌
non-sterile
化驗
≥98%
形狀
powder
mp
182-183 °C (lit.)
溶解度
ethanol: 50 mg/mL, clear, colorless to faintly yellow
運輸包裝
ambient
儲存溫度
room temp
SMILES 字串
[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])CCc4cc(O)ccc24
InChI
1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1
InChI 密鑰
BFPYWIDHMRZLRN-SLHNCBLASA-N
基因資訊
human ... ESR1(2099)
rat ... Afp(24177) , Esr1(24890) , Shbg(24775)
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一般說明
17α-乙炔雌二醇 (EE2) 是一种人工合成的激素，为雌二醇 (E2) 的衍生物。与雌激素替代治疗和暂停哺乳有关。EE2 用于治疗骨质疏松症、更年期和绝经后综合症。也用于治疗绝经后妇女的前列腺癌和乳腺癌。EE2 作为内分泌干扰物 (EDC) 发挥作用。
應用
17α-乙炔雌二醇已被用于研究外源性雌激素和选择性雌激素受体调节剂 (SERM) 在大鼠中的作用。它还被用于增加兔肝脏中低密度脂蛋白 (LDL) 受体的浓度。
生化／生理作用
17α-炔雌醇是一种口服生物活性合成雌激素，用作口服避孕药。
訊號詞
Danger
危險分類
Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 2 - Repr. 1A
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
其他客户在看
Huda Omar Ali et al.
PloS one, 11(3), e0152114-e0152114 (2016-03-22)
Oestrogens influence the pathology and development of hormone-sensitive breast cancers. Tissue factor pathway inhibitor (TFPI) has been shown to be associated with breast cancer pathogenesis. Recently, we found TFPI mRNA levels to be significantly reduced by oestrogens in a breast
Richard Mark Evans et al.
PloS one, 7(8), e43606-e43606 (2012-08-23)
A growing body of experimental evidence indicates that the in vitro effects of mixtures of estrogenic chemicals can be well predicted from the estrogenicity of their components by the concentration addition (CA) concept. However, some studies have observed small deviations
Admane H Shanthanagouda et al.
PloS one, 9(2), e88165-e88165 (2014-02-14)
In human, a reduction in estrogen has been proposed as one of the key contributing factors for postmenopausal osteoporosis. Rodents are conventional models for studying postmenopausal osteoporosis, but the major limitation is that ovariectomy is needed to mimic the estrogen
Analysis of 17-beta-estradiol and 17-alpha-ethinylestradiol in biological and environmental matrices?a review
Barreiros L, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 126, 243-262 (2016)
Anders E A Dahm et al.
BMC cardiovascular disorders, 6, 40-40 (2006-10-13)
Hormone therapy, oral contraceptives, and tamoxifen increase the risk of thrombotic disease. These compounds also reduce plasma content of tissue factor pathway inhibitor-1 (TFPI), which is the physiological inhibitor of the tissue factor pathway of coagulation. The current aim was
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