E3539

Proteinase 3 from human leukocytes

≥95% (PAGE)

• 别名: AGP7, Myeloblastin, P29B, PR-3, PR3 Ag
• EC 号: 3.4.21.76 (BRENDA, IUBMB)
• MDL號碼: MFCD03458212
• 分類程式碼代碼: 12352204
• NACRES: NA.54

属性

• 化驗: ≥95% (PAGE)
• 形狀: buffered aqueous solution
• UniProt登錄號: P24158
• 儲存溫度: −20°C
• 基因資訊: human ... PRTN3(5657)

说明

一般說明

Proteinase 3 is found in high concentration in the primary granules of myeloid leukemia blasts.⁴

應用

Proteinase 3 has been shown to be important in the pathogenesis of human emphysema.¹ It has also been used in a study to investigate the liberation of the antibacterial and cytotoxic peptide LL-37 by cleavage of human cathelicidin hCAP-183.²

生化／生理作用

Proteinase 3 (PR-3) is a serine protease expressed in the granules of neutrophils and monocytes. Also known as myeloblastin and p29b, it degrades elastin and is associated with myeloid leukemia and Wegener′s granulomatosis.³

Used for the detection of anti-PR3 auto-antibodies in immunoassays.

外觀

Solution in 50 mM sodium acetate (pH 5) with 600 mM sodium chloride

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable