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Merck

E1636

Sigma-Aldrich

β-Estradiol 3,17-disulfate dipotassium salt

≥95%

别名:

1,3,5(10)-Estratriene 3,17β-disulfate, 3,17β-Dihydroxy-1,3,5(10)-estratriene disulfate

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About This Item

线性分子式:
C18H22O8S2K2
CAS号:
分子量:
508.69
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

生物源

synthetic

化驗

≥95%

形狀

powder

技術

inhibition assay: suitable

溶解度

water: 50 mg/mL, clear, colorless

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

[K].[H][C@]12CC[C@]3(C)[C@H](CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24)OS(O)(=O)=O

InChI

1S/C18H24O8S2.K.H/c1-18-9-8-14-13-5-3-12(25-27(19,20)21)10-11(13)2-4-15(14)16(18)6-7-17(18)26-28(22,23)24;;/h3,5,10,14-17H,2,4,6-9H2,1H3,(H,19,20,21)(H,22,23,24);;/t14-,15-,16+,17+,18+;;/m1../s1

InChI 密鑰

CPIZVUIARARPNO-LBARCDFESA-N

生化/生理作用

Among other effects, this conjugated estrogen selectively inhibits glutathione S-transferases.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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J J Barycki et al.
Archives of biochemistry and biophysics, 345(1), 16-31 (1997-09-01)
3beta-(Iodoacetoxy)dehydroisoandrosterone (3beta-IDA), an analogue of the electrophilic substrate, Delta5-androstene-3,17-dione, as well as an analogue of several other steroid inhibitors of glutathione S-transferase, was tested as an affinity label of rat liver glutathione S-transferase, isozyme 1-1. A time-dependent loss of enzyme
Angelo Quaranta et al.
PloS one, 4(11), e7699-e7699 (2009-11-06)
Dramatic declines in amphibian populations have been described all over the world since the 1980s. The evidence that the sensitivity to environmental threats is greater in amphibians than in mammals has been generally linked to the observation that amphibians are
J D Bain et al.
Steroids, 43(6), 603-619 (1984-06-01)
The efficiencies for estrogen conjugate hydrolysis were compared between enzyme hydrolysis, acid solvolysis and a new method, ammonolysis. Samples included: 1) crystalline 1,3,5(10)-estratriene-3, 17 beta-diol disulfate (estradiol 3,17-disulfate), 2) squirrel monkey urine collected following an intravenous injection of [2,4,6,7-H] 1,3,5(10)-estratriene-3,17
A H Maas et al.
Nederlands tijdschrift voor geneeskunde, 145(2), 65-69 (2001-02-28)
Coronary heart disease develops on average 10-15 years later in women than in men and is uncommon before menopause. 17 beta-estradiol has atheroprotective properties through rapid vasodilatory effects on the endothelium by stimulating nitric monoxide production and longer-term actions by
Fanfan Zhou et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 27(5), 518-523 (2005-11-01)
Human organic anion transporter 4 (hOAT4) belongs to a family of organic anion transporters which play critical roles in the body disposition of clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories. hOAT4 is expressed in the

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