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Merck

E1257

Sigma-Aldrich

表皮生长因子 来源于鼠颔下腺

lyophilized powder, BioReagent, suitable for cell culture

别名:

EGF, 表皮细胞生长因子

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About This Item

CAS号:
EC號碼:
MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.32

生物源

mouse submaxillary glands

品質等級

產品線

BioReagent

化驗

≥98% (SDS-PAGE)

形狀

lyophilized powder

效力

0.02-2.0 ng/mL EC50

包裝

pkg of 0.1 mg

儲存條件

avoid repeated freeze/thaw cycles

技術

cell culture | mammalian: suitable

雜質

endotoxin, tested

顏色

white

UniProt登錄號

儲存溫度

2-8°C

基因資訊

mouse ... Egf(13645)

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一般說明

Epidermal growth factor (EGF) is the member of EGF-like family of growth factors, that binds to EGF receptor. It is majorly expressed in kidney, parotid gland and salivary gland.

應用

Epidermal Growth Factor from murine submaxillary gland has been used
  • in studying its effects on the development of caustic esophageal stricture in rats
  • for preparation of MCF-10A cell line
  • for the culture of primary hair follicle stem cells from arbas cashmere goat (gHFSCs) and adhesion of hair follicles (HF)

生化/生理作用

Epidermal growth factor (EGF) blocks gastric acid and pepsin secretion and increases gastrointestinal cell proliferation. EGF stimulates proliferation and migration in bone marrow stromal cells (BMSC), that gives rise to osteoblasts, chondrocytes and adipocytes. It functions as a strong mitogenic factor for various cultured cells. Mutations in this gene is linked to hypomagnesemia. EGF plays a major role in the maintenance of hair and skin development.

外觀

Lyophilized from 0.2 μm filtered solution in ammonium acetate buffer.

準備報告

Purified by gel filtration and ion-exchange chromatography.

分析報告

The biological activity is measured in a proliferation assay using BALB/MK cells.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Subcellular localization of epidermal growth factor receptor in human submandibular gland
Lantini MS, et al.
Journal of Anatomy, 208(5), 595-599 (2006)
High-sensitivity TFA-free LC-MS for profiling histones
You J, et al.
Proteomics, 11(16), 3326-3334 (2011)
Expression of epidermal growth factor in human tissues
Kajikawa K, et al.
Virchows Archiv. A, Pathological Anatomy and Histopathology, 418(1), 27-32 (1991)
Effects of caffeic acid phenethyl ester and epidermal growth factor on the development of caustic esophageal stricture in rats
Koltuksuz U, et al.
Journal of Pediatric Surgery, 36(10), 1504-1509 (2001)
Epidermal growth factor promotes proliferation of dermal papilla cells via Notch signaling pathway
Zhang H, et al.
Biochimie, 127(21), 10-18 (2016)

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