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化驗
≥98% (HPLC)
品質等級
形狀
powder
顏色
light yellow to yellow
溶解度
DMSO: 1 mg/mL, clear, faintly yellow to greenish-yellow
應用
metabolomics
vitamins, nutraceuticals, and natural products
儲存溫度
2-8°C
SMILES 字串
COc1ccc(cc1O)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI
1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3
InChI 密鑰
MBNGWHIJMBWFHU-UHFFFAOYSA-N
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一般說明
香叶木素是地奥司明的甲基化苷元黄酮。它大量存在于柑橘类水果， 油橄榄 L （橄榄树）的树叶，和豆科 金合欢 树中。
應用
香叶木素已被用于测试其对小鼠模型的慢性压力记忆和认知障碍的保护作用。
生化／生理作用
香叶木素表现出抗炎、抗癌、抗微生物、植物雌激素和保护神经的特性。它通过抑制核苷酸结合结构域(NOD)样受体蛋白3(NLRP3)炎性体和激活核因子红细胞2相关因子2(Nrf2)，显示出对脂多糖(LPS)诱导的急性肺损伤(ALI)的细胞保护作用。
柑橘柠檬中的类黄酮。抗氧化剂。通过抑制CYP1A1酶抑制致癌物活化。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
A review on pharmacological and analytical aspects of diosmetin: a concise report.
Patel, et al.
Chinese Journal of Integrative Medicine, 19, 792-800 (2018)
Elham Saghaei et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 5725361-5725361 (2021-01-09)
In the present experimental study, male NMRI mice were exposed to chronic unpredictable mild stress (CUMS) paradigm for 35 days. Diosmetin (at doses of 10, 20, and 40 mg/kg. i.p.) or diosmetin solvent (normal saline + DMSO, 1 ml/kg; i.p.) was administered 30 min before
Qinmei Liu et al.
Biomolecules & therapeutics, 26(2), 157-166 (2017-04-04)
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common clinical syndrome of diffuse lung inflammation with high mortality rates and limited therapeutic methods. Diosmetin, an active component from Chinese herbs, has long been noticed because of its antioxidant
Vasilis P Androutsopoulos et al.
The Journal of nutritional biochemistry, 24(2), 496-504 (2012-07-04)
Various types of tumors are known to overexpress enzymes belonging to the CYP1 family of cytochromes P450. The present study aimed to characterize the metabolism and further antiproliferative activity of the natural flavonoid diosmetin in the CYP1-expressing human hepatoma cell
Luigi Quintieri et al.
Biochemical pharmacology, 75(6), 1426-1437 (2008-01-15)
We evaluated the effects of increasing concentrations of the flavonoids salvigenin, diosmetin and luteolin on the in vitro metabolism of midazolam (MDZ), a probe substrate for cytochrome P450 (CYP) 3A enzymes, which is converted into 1'-hydroxy-midazolam (1'-OH-MDZ) and 4-hydroxy-midazolam (4-OH-MDZ)
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