D6196

Dimebon dihydrochloride hydrate

≥98% (HPLC)

• 别名: 2,8-Dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride hydrate, Dimebolin dihydrochloride hydrate, Dimeboline dihydrochloride hydrate, Dimebone dihydrochloride hydrate
• 经验公式（希尔记法）: C₂₁H₂₅N₃ · 2HCl · xH₂O
• CAS号: 97657-92-6
• 分子量: 392.37 (anhydrous basis)
• MDL號碼: MFCD17215933
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329798824
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to off-white
• 溶解度: H₂O: ≥10 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: O.Cl.Cl.CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccc(C)nc4
• InChI: 1S/C21H25N3.2ClH.H2O/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17;;;/h4-7,12-13H,8-11,14H2,1-3H3;2*1H;1H2
• InChI 密鑰: QQHQMWVYYVVAOV-UHFFFAOYSA-N

说明

生化／生理作用

Mechanism of neuroprotection and cognition enhancement is not certain, but Dimebon blocks both cholinesterase and the NMDA receptor simultaneously and also appears to block the action of neurotoxic β-amyloid proteins and inhibit L-type calcium channels, and may exert a neuroprotective effect by blocking a novel target that involves mitochondrial pores.

特點和優勢

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H315,H319
• 防範說明: P264 - P270 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable