所有图片(1)
About This Item
经验公式（希尔记法）:
C20H26O4
CAS号:
分子量:
330.42
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.25
推荐产品
生物源
Rosemarinus officinalis L.
形狀
powder
應用
metabolomics
vitamins, nutraceuticals, and natural products
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
CC(C)c1cc2[C@@H]3C[C@H]4C(C)(C)CCC[C@]4(C(=O)O3)c2c(O)c1O
InChI
1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
InChI 密鑰
XUSYGBPHQBWGAD-PJSUUKDQSA-N
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一般說明
卡诺醇(CAR)是一种邻二酚二萜，提取自地中海草本植物迷迭香(Rosmarinus officinalis L. )。它最初是从鼠尾草(Sage)植物中分离出来的。卡诺醇也是亲电子分子。
應用
卡诺醇已被用作一种抗癌剂：
- 测试其对肿瘤干细胞样细胞(CSC)和多形性成胶质细胞瘤 (GBM)细胞
- 的抗癌及抗增殖作用，以在人类宫颈癌模型中，检测其对不同遗传致癌途径上、下调节的19个基因以及对海拉细胞的抗癌作用
- 作为参考标准品，采用液相色谱-串联质谱(LC/ESI-MS/MS)对迷迭香提取物的代谢物进行鉴定和定量
生化／生理作用
麝香醇和鼠尾草酸(CA)的抗氧化活性占迷迭香叶的90%。在慢性应激条件下，它具有神经保护特性，可以防止神经炎症和氧化应激诱导的脑损伤。卡诺醇是一种强效化疗药物，研究用于多种类型的癌症，如乳腺癌、白血病、皮肤癌、前列腺癌和结肠癌。它也可用作抗菌剂。
一种具有抗氧化和抗癌活性的酚类二萜。
訊號詞
Warning
危險聲明
危險分類
Skin Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
The anticancer molecular mechanism of Carnosol in human cervical cancer cells: An in vitro study
Hafidha RR and Abdulamirb AS
Asia-Pacific Journal of Molecular Biology and Biotechnology, 88-98 (2020)
Marcos Roberto de Oliveira
Molecular neurobiology, 53(9), 6155-6168 (2016-11-01)
Carnosic acid (CA) and carnosol are the major diterpenes found in Rosmarinus officinalis (rosemary), a culinary spice. CA and carnosol account for over 90 % of its anti-oxidant activity in rosemary leaves. The diterpenes exert anti-oxidant, anti-inflammatory, and anti-carcinogenic activities, and
Saeed Samarghandian et al.
BMC complementary and alternative medicine, 17(1), 249-249 (2017-05-06)
Oxidative stress through chronic stress destroys the brain function. There are many documents have shown that carnosol may have a therapeutic effect versus free radical induced diseases. The current research focused the protective effect of carnosol against the brain injury
N Mulinacci et al.
Talanta, 85(1), 167-176 (2011-06-08)
The Rosmarinus officinalis L. is widely known for its numerous applications in the food field but also for the increasing interest in its pharmaceutical properties. Two groups of compounds are mainly responsible for the biological activities of the plant: the
Yosei Tamaki et al.
Planta medica, 76(7), 683-688 (2009-11-27)
In our previous studies, we have reported that carnosic acid (CA) and carnosol (CS) originating from rosemary protects cortical neurons by inducing phase 2 enzymes, the induction of which was initiated by activation of the Keap1/Nrf2 pathway , , .
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