推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 62 kDa
物種活性
human, mouse, hamster
技術
indirect immunofluorescence: 1:30
microarray: suitable
western blot: 1:100
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... CCNB1(891)
mouse ... Ccnb1(268697)
一般說明
The cyclin B1 (CCNB1) gene is mapped to human chromosome 5q13.2. The gene codes for a 62kDa protein containing a classical cyclin box domain. CCNB1 shuttles between the nucleus and cytoplasm until prophase begins. It is a member of the cyclin family and is expressed at low levels in normal cells.
免疫原
recombinant hamster cyclin B1
應用
Anti-cyclin B1 antibody produced in rabbit has been used in western blotting.
生化／生理作用
Cyclin B1 (CCNB1) and cyclin-dependent kinase 1 (CDK1) complex play a crucial role in regulation of mitosis. Elevated expression of the gene has been observed in various types of human cancers including breast, lung, colon, prostate and head and neck cancers. Thus, this protein can be considered as a potent target for cancer vaccines. In addition, CCNB1 also serves as a prognostic biomarker for estrogen-receptor-positive (ER+) breast cancer.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
CCNB1 is a prognostic biomarker for ER+ breast cancer
Ding K, et al.
Medical Hypotheses, 83, 359-364 (2014)
Chk1-induced CCNB1 overexpression promotes cell proliferation and tumor growth in human colorectal cancer
Fang Y, et al.
Cancer Biology & Therapy, 15, 1268-1279 (2014)
Virus infection disturbs cyclin expression, leading to cell cycle arrest in the unicellular marine algae Emiliania huxleyi and Chrysochromulina ericina
Liu et al.
African Journal of Microbiology Research, 5(14), 1801-1807 (2011)
Virus infection disturbs cyclin expression, leading to cell cycle arrest in the unicellular marine algae Emiliania huxleyi and Chrysochromulina ericina
Liu J, et al.
African Journal of Microbiology Research, 5, 1801-1807 (2011)
Importance of tuberin in carcinogenesis.
Jin M, et al.
Oncology Letters, 14, 2598-2602 (2017)
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