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Key Documents

C8032

Sigma-Aldrich

α-酪蛋白脱磷酸化 来源于牛奶

lyophilized powder

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About This Item

CAS号:
9000-71-9
MDL號碼:
MFCD00130477
分類程式碼代碼:
12352202
NACRES:
NA.61

生物源

bovine milk

化驗

≥70% (biuret)

形狀

lyophilized powder

技術

surface plasmon resonance (SPR): suitable

儲存溫度

−20°C

InChI

1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)

InChI 密鑰

BECPQYXYKAMYBN-UHFFFAOYSA-N

基因資訊

bovine ... MACAS(100532647) , MACASP(105753520)

應用

α来自牛乳的-酪蛋白是属于酪蛋白磷蛋白家族的免疫球蛋白E（IgE）结合表位。由于α-酪蛋白抗体与胰岛素之间的强交叉反应性，它已被用于儿童胰岛素依赖型糖尿病（IDDM）的研究中。对表现出（IDDM）症状儿童的研究表明，他们相对于对照组同胞的α-酪蛋白抗体水平更高，而这可能是IDDM的一种风险标志物。

生化／生理作用

酪蛋白中的磷酸丝氨酸簇可螯合铁并降低其生物利用度。酪蛋白的部分酶消化可将磷酸化的残基暴露给碱性磷酸酶，从而实现去磷酸化并提高铁的生物利用度。

品質

至少80％的去磷酸化。

準備報告

从C6780采用酶法制备的。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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O Vaarala et al.
Diabetes, 48(7), 1389-1394 (1999-07-02)
Insulin autoantibodies (IAAs) often appear as the first sign of islet cell autoimmunity in prediabetic children. Because cow's milk contains bovine insulin, we followed the development of insulin-binding antibodies in children fed with cow's milk formula. Bovine insulin- and human
T Saukkonen et al.
Diabetologia, 41(1), 72-78 (1998-03-14)
Dietary factors are suspected to play an aetiological role in the development of insulin-dependent diabetes mellitus (IDDM). We analysed cow's milk formula, betalactoglobulin, and bovine serum albumin antibodies by an enzyme-linked immunoassay in unselected children with newly diagnosed IDDM and
Saima Nasir et al.
ChemPlusChem, 85(3), 587-594 (2020-03-28)
We report a nanofluidic device for the label-free detection of phosphoprotein (PPn) analytes. To achieve this goal, a metal ion chelator, namely 4-[bis(2-pyridylmethyl)aminomethyl]aniline (DPA-NH2 ) compound was synthesized. Single asymmetric nanofluidic channels were fabricated in polyethylene terephthalate (PET) membranes. The
A Maucuer et al.
European journal of biochemistry, 267(14), 4456-4464 (2000-07-06)
We present here a first appraisal of the phosphorylation site specificity of KIS (for 'kinase interacting with stathmin'), a novel mammalian kinase that has the unique feature among kinases to possess an RNP type RNA-recognition motif (RRM). In vitro kinase

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