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Key Documents

L9507

Sigma-Aldrich

乳铁蛋白 来源于牛奶

≥85% (SDS-PAGE)

别名:

Bos d LF, Lactotransferrin

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.61

生物源

bovine milk

品質等級

化驗

≥85% (SDS-PAGE)

形狀

powder

分子量

~87 kDa

技術

fractionation: suitable

溶解度

H2O: soluble 10 mg/mL

UniProt登錄號

儲存溫度

2-8°C

基因資訊

cow ... LTF(280846)

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應用

乳铁蛋白被用于通过阳离子交换膜从牛体内分离乳过氧化物酶和乳铁蛋白。它被用于通过新型免疫传感器测定动物乳汁中的乳铁蛋白和免疫球蛋白G。

生化/生理作用

乳铁蛋白是一种铁结合蛋白。 它的结构与转铁蛋白类似,即血浆铁转运蛋白;但乳铁蛋白对铁的亲和力要高得多(250倍)。它在初乳中的含量非常高,并且在泪液、唾液、粘液分泌物和中性粒细胞的次级颗粒中也少量存在。它由粘膜上皮和嗜中性粒细胞产生,由这些细胞在炎症刺激下释放。乳铁蛋白可以通过与铁螯合而抑制细菌生长,并且通过其N-末端与脂多糖结合而增加细菌细胞壁通透性。乳铁蛋白可以通过与病毒包膜蛋白紧密结合而抑制病毒感染。这能够阻断细胞与病毒的结合域,从而防止细胞-病毒融合。乳铁蛋白可能通过刺激白细胞介素-8(一种中性粒细胞激活剂)的释放而激活宿主防御系统。 它还可能参与抗体和白细胞介素合成、淋巴细胞增殖和补体激活。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Fractionation of Lactoperoxidase and Lactoferrin from Bovine Whey Using a Cation Exchange Membrane
Clovis k. Chiu and Mark R.
Journal of Food Science, 62, 996-1000 (1997)
Víctor A Solarte et al.
BioMed research international, 2015, 630179-630179 (2015-11-27)
Several short linear peptides derived from cyclic bovine lactoferricin were synthesized and tested for their cytotoxic effect against the oral cavity squamous-cell carcinoma (OSCC) cell lines CAL27 and SCC15. As a control, an immortalized and nontumorigenic cell line, Het-1A, was
O Oyen et al.
FEBS letters, 229(2), 391-394 (1988-03-14)
Cyclic AMP (cAMP) and its action by way of cAMP-dependent protein kinase is important for sperm motility. Previous studies on germ cells have demonstrated a selective decrease in the amount of type I cAMP-dependent protein kinase during spermatid development, and
Mona M Abdel-Wahab et al.
Fish & shellfish immunology, 111, 160-169 (2021-02-09)
The present study was carried out to investigate the effects of dietary bovine lactoferrin (BLF) or chitosan nanoparticles (CHN) alone or in combinations on serum biochemical indices, antioxidative capacity, transcriptomic responses, non-specific immunity, and resistance of Nile tilapia (Oreochromis niloticus)
Qianqian Yao et al.
PeerJ, 9, e11072-e11072 (2021-06-17)
Colorectal cancer is a common cause of death with few available therapeutic strategies, and the preventative complexes in adjunctive therapy are urgently needed. Increasing evidences have shown that natural ingredients, including lactoferrin, oleic acid, docosahexaenoic acid (DHA) and linolenic acid

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