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Key Documents

C6374

Sigma-Aldrich

Caerulomycin A

from Streptomyces caeruleus, ≥98% (HPLC)

别名:

Carulomycin A, Cerulomycin

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About This Item

经验公式(希尔记法):
C12H11N3O2
CAS号:
分子量:
229.23
MDL號碼:
分類程式碼代碼:
51111800
PubChem物質ID:
NACRES:
NA.77

价格与库存信息目前不能提供

生物源

Streptomyces caeruleus

品質等級

化驗

≥98% (HPLC)

形狀

powder

抗生素活性譜

fungi

儲存溫度

−20°C

SMILES 字串

COc1cc(\C=N\O)nc(c1)-c2ccccn2

InChI

1S/C12H11N3O2/c1-17-10-6-9(8-14-16)15-12(7-10)11-4-2-3-5-13-11/h2-8,16H,1H3/b14-8+

InChI 密鑰

JCTRJRHLGOKMCF-RIYZIHGNSA-N

生化/生理作用

Caerulomycins produced by Streptomyces caeruleus are bipyridinic molecules endowed with antibiotic properties. Caerulomycin A was found to have a strong anti-fungal and anti-amoebic activity, and a mild antibacterial activity.

準備報告

Caerulomycin A stock solution may be prepared in DMSO or methanol at 1 mg/mL. The stock solution can be further diluted in water to 0.1 mg/mL. Higher concentrations my requrie gentle heating to 40 °C. Dilutions from the stock solution should be freshly prepared.

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

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    Qinheng Lin et al.
    Wei sheng wu xue bao = Acta microbiologica Sinica, 51(8), 1032-1041 (2011-11-22)
    In order to enable the caerulomyicn biosynthetic study by in vivo gene disruptions, it is crucial to develop a genetic modification system for the producer Actinoalloteichus sp. WH1-2216-6. The spore germination timing and the concentration of MgSO4 in the medium
    Tarek Sammakia et al.
    Organic letters, 4(14), 2385-2388 (2002-07-06)
    [reaction: see text] The total synthesis of caerulomycin C is described. Key steps in this synthesis utilize 1,2-, 1,3-, and 1,4-halogen dance reactions for the functionalization of the pyridine ring.
    D K Chatterjee et al.
    Zeitschrift fur Parasitenkunde (Berlin, Germany), 70(5), 569-573 (1984-01-01)
    The anti-amoebic action of the bipyridyl antibiotic caerulomycin was assessed in vitro and in vivo using various strains of Entamoeba histolytica from polyxenic, axenic and monoxenic cultures. Minimum inhibition concentrations of caerulomycin (metronidazole) were 7.5 (5), 15.6(1.95) and 60 (2.5)

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