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Merck

C6048

Sigma-Aldrich

头孢美他唑 钠盐

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About This Item

线性分子式:
C15H16N7O5S3Na
CAS号:
分子量:
493.52
MDL號碼:
分類程式碼代碼:
51282205
PubChem物質ID:
NACRES:
NA.85

形狀

powder

品質等級

儲存期限

limited shelf life, expiry date on the label

溶解度

H2O: 50 mg/mL

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

cell wall synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

[Na+].[H][C@]12SCC(CSc3nnnn3C)=C(N1C(=O)[C@]2(NC(=O)CSCC#N)OC)C([O-])=O

InChI

1S/C15H17N7O5S3.Na/c1-21-14(18-19-20-21)30-6-8-5-29-13-15(27-2,17-9(23)7-28-4-3-16)12(26)22(13)10(8)11(24)25;/h13H,4-7H2,1-2H3,(H,17,23)(H,24,25);/q;+1/p-1/t13-,15+;/m1./s1

InChI 密鑰

BITQGIOJQWZUPL-PBCQUBLHSA-M

一般說明

Chemical structure: ß-lactam

應用

Cefmetazole is used to study the effect of expression, binding, and inhibition of penicillin-binding proteins (PDPs) other than PBP2 on bacterial cell wall mucopeptide synthesis. Cefmetazole is used to study protein mediated transport of antibiotics.

生化/生理作用

Cefmetazole disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Cefmetazole mimics the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan. It is effective against both Gram-positive and Gram-negative bacteria.

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

其他說明

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic Handle and store under inert gas.

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險分類

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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Xing-Yi Zhang et al.
Zhonghua nei ke za zhi, 50(4), 295-298 (2011-05-24)
To evaluate the efficacy and safety of intravenous cefmetazole in the treatment of patients with aspiration pneumonia. A multicenter, prospective and open-labeled trial was conducted. A total of 1522 patients were enrolled at the beginning, and only 1324 were evaluated
Hirotoshi Okumura et al.
Toxicological sciences : an official journal of the Society of Toxicology, 97(2), 533-538 (2007-03-08)
The liver of a chimeric urokinase-type plasminogen activator (uPA)(+/+)/severe combined immunodeficient (SCID) mouse line recently established in Japan could be replaced by more than 80% with human hepatocytes. We previously reported that the chimeric mice with humanized liver could be
Osamu Ishikawa et al.
Experimental animals, 67(4), 501-508 (2018-08-03)
The aim of this study was to propose a new animal model evaluating the serial time course of in-stent stenosis by repeated carotid artery catheterization in the same animal. 16 bare-metal stents were implanted in the normal external and internal
Junzo Shimizu et al.
Surgery today, 40(10), 954-957 (2010-09-28)
Postoperative antimicrobial therapy is generally administered as standard prophylaxis against postoperative infection, despite a lack of sufficient evidence for its usefulness. This study was a phase II study to evaluate the necessity of postoperative antibiotic prophylaxis in patients undergoing a
Masaaki Machino et al.
Orthopedics, 34(11), e793-e795 (2011-11-05)
The bacterium Pasteurella haemolytica is resident in the oral cavities of dogs and cats and is often a cause of zoonotic infection. However, it is rare for it to be the pathogenic bacteria behind pyogenic spondylitis, and few studies have

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