所有图片(4)
About This Item
线性分子式:
ClC6H4CH2CH(NH2)CO2CH3·HCl
CAS号:
分子量:
250.12
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.32
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形狀
powder
mp
186-189 °C (lit.)
儲存溫度
−20°C
SMILES 字串
Cl.COC(=O)C(N)Cc1ccc(Cl)cc1
InChI
1S/C10H12ClNO2.ClH/c1-14-10(13)9(12)6-7-2-4-8(11)5-3-7;/h2-5,9H,6,12H2,1H3;1H
InChI 密鑰
GCBCWTWQAFLKJG-UHFFFAOYSA-N
基因資訊
human ... TPH1(7166) , TPH2(121278)
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一般說明
4-氯-DL-苯丙氨酸甲酯盐酸盐刺激妊娠小鼠的葡萄糖耐受不良。研究表明4-氯-DL-苯丙氨酸甲酯盐酸盐与啮齿动物的认知缺陷有关。
應用
4-氯- DL -苯丙氨酸甲酯盐酸盐已用于诱导大鼠 5-羟色胺 (5-HT) 耗竭。
生化／生理作用
色氨酸羟化酶抑制剂。比对氯苯基丙氨酸更易穿越血脑屏障。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Jessica E Monk et al.
Frontiers in behavioral neuroscience, 12, 246-246 (2018-11-09)
Negative affective states such as anxiety and depression pose a risk to animal welfare, however, practical tests for assessing these states in animals are limited. In humans, anxious individuals are shown to pay more attention toward threatening information than non-anxious
Serotonin regulates pancreatic beta cell mass during pregnancy
Kim H, et al.
Nature Medicine, 16(7), 804-804 (2010)
Serotonin depletion results in a decrease of the neuronal activation caused by rivastigmine in the rat hippocampus
Kornum BR, et al.
Brain Research, 1073, 262-268 (2006)
Vortioxetine dose-dependently reverses 5-HT depletion-induced deficits in spatial working and object recognition memory: a potential role for 5-HT1A receptor agonism and 5-HT3 receptor antagonism
du Jardin KG, et al.
European Neuropsychopharmacology, 24(1), 160-171 (2014)
F Denk et al.
Psychopharmacology, 179(3), 587-596 (2005-05-03)
Although tasks assessing the role of dopamine in effort-reward decisions are similar to those concerned with the role of serotonin in impulsive choice in that both require analysis of the costs and benefits of possible actions, they have never been
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