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應用
Sigma 公司的碳酸酐酶已被用于通过测量结合亲和力和化学计量学来分析酶的热力学稳定性。在大鼠自身免疫性胰腺炎研究期间，还使用该酶生成了对碳酸酐酶特异性的 CD 4 + T 细胞系。
生化／生理作用
碳酸酐酶是一种锌金属酶，分子量约为 30,000 Da。这种酶催化二氧化碳水合生成碳酸。参与 pH 和 CO 2 动态平衡、碳酸氢盐和 CO 2 的转运、生物合成反应、骨吸收、钙化、致瘤等许多生理和病理过程。因此，阻断该酶的抑制剂可能对青光眼、癫痫和帕金森氏病具有治疗意义。
單位定義
一个 Wilbur-Anderson (W-A) 单位每分钟将导致 0.02 MTrizma 缓冲液的 pH 值在 0°C 下从 8.3 降至 6.3（一个 W-A 单位基本上相当于一个 Roughton-Booth 单位）。
訊號詞
Danger
危險聲明
危險分類
Resp. Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Amelia Pollard et al.
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Carbonic anhydrase inhibitors are used to treat glaucoma and cancers. Carbonic anhydrases perform a crucial role in the conversion of carbon dioxide and water into bicarbonate and protons. However, there is little information about carbonic anhydrase isoforms during the process
Maria M Garcia-Alai et al.
Nature communications, 9(1), 328-328 (2018-01-25)
In clathrin-mediated endocytosis, adapter proteins assemble together with clathrin through interactions with specific lipids on the plasma membrane. However, the precise mechanism of adapter protein assembly at the cell membrane is still unknown. Here, we show that the membrane-proximal domains
Todd S Davidson et al.
The American journal of pathology, 166(3), 729-736 (2005-03-04)
Autoimmune pancreatitis (AIP), a recently defined disease of unknown etiology, is characterized by inflammatory infiltrates in the pancreas with conspicuous involvement of the ducts. The disease clinically manifests in humans as epigastric pain, weight loss, and jaundice. This report describes
Daumantas Matulis et al.
Biochemistry, 44(13), 5258-5266 (2005-03-30)
ThermoFluor (a miniaturized high-throughput protein stability assay) was used to analyze the linkage between protein thermal stability and ligand binding. Equilibrium binding ligands increase protein thermal stability by an amount proportional to the concentration and affinity of the ligand. Binding
Leo Syrjänen et al.
Journal of medicinal chemistry, 56(18), 7372-7381 (2013-08-28)
Leishmaniasis is an infection provoked by protozoans belonging to the genus Leishmania. Among the many species and subsepecies of such protozoa, Leishmania donovani chagasi causes visceral leishmaniasis. A β-carbonic anhydrase (CA, EC 4.2.1.1) was cloned and characterized from this organism
实验方案
Objective: To standardize a procedure for the enzymatic assay of Carbonic Anhydrase (EC 4.2.1.1) for Wilbur-Anderson Units.
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