推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
lyophilized powder
物種活性
rat
技術
western blot: 1:200 using lysate from the ND7/23 cell line
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
rat ... Cacna1h(114862)
一般說明
钙通道，电压依赖性，T型，α1H亚基（CACNA1H）是人类中由CACNA1H基因编码的蛋白，并定位于16p13.3号染色体。蛋白质是膜蛋白机制，可选择性渗透外部钙离子。α1H通道对米贝拉地尔（一种非二氢吡啶Ca2+ 通道阻滞剂）敏感。CACNA1H在初级传入神经元的外周和中枢末端大量表达，调节神经元兴奋性和兴奋性神经递质的释放。
免疫原
对应于大鼠CaV3.2氨基酸残基581-595的合成肽CHVEGPQERARVAHS。表位位置：连接D1-D2的细胞内环。小鼠，牛和犬具有14/15个相同的残基；人具有13/15个相同的残基。
生化／生理作用
钙通道，电压依赖性，T型，α1H亚基（CACNA1H）在调节大脑中的神经元兴奋性和网络振荡中起着至关重要的作用。该基因的突变与各种形式的特发性全身性癫痫有关。CACNA1H中的功能获得突变通过直接改变神经元电学特性和通过改变基因表达间接增加癫痫发作敏感性。CACNA1H是静息膜电位附近Ca2+进入的重要介体。它在疼痛信号的处理中起着关键作用，并且可以作为开发用于对目前可用的镇痛药具有抗性的顽固性疼痛的治疗的药物的新靶标。CACNA1H上调参与炎症性，神经性和内脏疼痛的病理生理。
外觀
从含有1%牛血清白蛋白和0.05%叠氮化钠的磷酸盐缓冲盐水（pH 7.4）中冻干。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Pierre-Olivier Demers-Giroux et al.
The Journal of biological chemistry, 288(41), 29281-29293 (2013-08-24)
T-type CaV3 channels are important mediators of Ca(2+) entry near the resting membrane potential. Little is known about the molecular mechanisms responsible for channel activation. Homology models based upon the high-resolution structure of bacterial NaV channels predict interaction between the
Despina Tsortouktzidis et al.
Frontiers in molecular neuroscience, 14, 667143-667143 (2022-01-25)
Precise genome editing in combination with viral delivery systems provides a valuable tool for neuroscience research. Traditionally, the role of genes in neuronal circuits has been addressed by overexpression or knock-out/knock-down systems. However, those techniques do not manipulate the endogenous
Hyun-Jee Park et al.
Cell calcium, 54(3), 226-235 (2013-07-16)
Voltage-activated Ca2+ channels are membrane protein machinery performing selective permeation of external calcium ions. The main Ca2+ selective filters of all high-voltage-activated Ca2+ channel isoforms are commonly composed of four Glu residues (EEEE), while those of low-voltage-activated T-type Ca2+ channel
K E Rose et al.
Neuroscience, 250, 263-274 (2013-07-23)
Previous behavioral studies have revealed that CaV3.2 T-type calcium channels support peripheral nociceptive transmission and electrophysiological studies have established the presence of T-currents in putative nociceptive sensory neurons of dorsal root ganglion (DRG). To date, however, the localization pattern of
Veit-Simon Eckle et al.
The Journal of physiology, 592(4), 795-809 (2013-11-28)
T-type calcium channels play essential roles in regulating neuronal excitability and network oscillations in the brain. Mutations in the gene encoding Cav3.2 T-type Ca(2+) channels, CACNA1H, have been found in association with various forms of idiopathic generalized epilepsy. We and
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