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Merck

B3931

Sigma-Aldrich

Bisindolylmaleimide X hydrochloride

≥90%, solid

别名:

Ro 31-8425

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About This Item

经验公式(希尔记法):
C26H24N4O2 · HCl
分子量:
460.96
MDL號碼:
分類程式碼代碼:
12352111
PubChem物質ID:
NACRES:
NA.77

生物源

synthetic (organic)

品質等級

化驗

≥90%

形狀

solid

溶解度

DMSO: soluble

儲存溫度

−20°C

SMILES 字串

Cl.Cn1cc(C2=C(C(=O)NC2=O)c3c4CC(CN)CCn4c5ccccc35)c6ccccc16

InChI

1S/C26H24N4O2.ClH/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30;/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32);1H

InChI 密鑰

IMBOYWXMTUUYGZ-UHFFFAOYSA-N

應用

Bisindolylmaleimide X hydrochloride has been used as a protein kinase C (PKC) inhibitor:
  • in chemotaxis assays
  • to inhibit protein kinase C and to study its effects on the expression of EGR1, NAB2, ZEBRA, and Rta
  • in the culture to study its effects on the expression of the kinase-insert domain-containing receptor (KDR)-B1, protein kinase Cθ (PKCθ)-M1a or Abl-HTa and on cell yield in baculovirus (BV)-infected insect cells

生化/生理作用

Bisindolylmaleimide X hydrochloride/Ro 31-8425, a strong and selective protein kinase C (PKC) inhibitor, can reduce the superoxide burst caused by various agonists in neutrophils. It can suppress the responses induced by cell surface receptors and phorbol esters in T cells. In humans, Ro 31-8425 can prevent neutrophil PKC in vitro with an IC50 of 5nM.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Jianjiang Ye et al.
Journal of virology, 84(23), 12405-12418 (2010-09-24)
The Epstein-Barr virus (EBV) lytic activator genes bzlf1 and brlf1 are conventionally referred to as immediate-early (IE) genes. However, previous studies showed that the earliest expression of these genes was blocked by cycloheximide when the EBV lytic cycle was induced

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