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Merck
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文件

B169

Sigma-Aldrich

BRL 37344 钠盐 水合物

solid

别名:

(±)-(R*,R*)- [4- [2- [ [2-（3-氯苯基）-2-羟乙基] 氨基] 丙基] 苯氧基] 乙酸钠 水合物, BRL 37344A

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About This Item

经验公式（希尔记法）:
C19H21ClNNaO4 · xH2O
CAS号:
127299-93-8
分子量:
385.82 (anhydrous basis)
分類程式碼代碼:
12352200
PubChem物質ID:
24277764
NACRES:
NA.77

化驗

≥98% (HPLC)

品質等級

100

形狀

solid

顏色

white

溶解度

DMSO: 18 mg/mL, clear (warmed)

SMILES 字串

O.[Na+].C[C@H](Cc1ccc(OCC([O-])=O)cc1)NC[C@H](O)c2cccc(Cl)c2

InChI

1S/C19H22ClNO4.Na.H2O/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24;;/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24);;1H2/q;+1;/p-1/t13-,18+;;/m1../s1

InChI 密鑰

YTPAKDODIXRQTF-BNTHFPBMSA-M

基因資訊

human ... ADRB3(155)

生化／生理作用

BRL 37344 是一种选择性 β3肾上腺素受体激动剂。研究支持外周 β3肾上腺素能受体，能减少食物摄入，中枢 β 2或 β 3肾上腺素能受体介导 β3激动剂的外围效应。

特點和優勢

该化合物在受体分类和信号转导手册中β-肾上腺素能受体页面中进行了详细介绍。想要浏览手册的其他页面， 请单击此处。

注意

吸湿性；干燥储存。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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M A Oriowo et al.
The Journal of pharmacology and experimental therapeutics, 277(1), 22-27 (1996-04-01)
The stimulation by BRL 37344 of lipolysis in rat adipose tissues, and of relaxation of the rat distal colon, is mediated by the beta-3 adrenoceptor. The stereochemical requirements of the beta-3 adrenoceptor are poorly understood. The activities of the four
S Tsujii et al.
Physiology & behavior, 63(4), 723-728 (1998-04-02)
This study evaluated the effect of peripheral injections of a beta3 adrenergic agonist, BRL-37,344 on food intake and whether this inhibition could be blocked by a nonspecific beta-adrenergic antagonist, propranolol, given peripherally or into the central nervous system. When BRL-37,344
K Koike et al.
European journal of pharmacology, 334(2-3), 217-221 (1997-11-22)
Beta-adrenoceptor-mediated relaxation of guinea pig taenia caecum was investigated by studying the effects of the beta3-adrenoceptor agonists, BRL37344A [(R*,R*)-(+/-)-4-[2'-[2-hydroxy-2-(3-chlorophenyl) ethylamino] propyl] phenoxyacetic acid sodium salt sesquihydrate] and BRL35135A [(R*,R*)-(+/-)-methyl-4-[2-[2-hydroxy-2-(3-chlorophenyl) ethylamine] propyl] phenoxyacetate hydrobromide]. BRL37344A and BRL35135A caused dose-dependent relaxation of
Junyu Lai et al.
Journal of cellular biochemistry, 120(10), 17872-17886 (2019-06-05)
Partial bladder outlet obstruction (PBOO) promotes bladder detrusor hyperplasia, increases bladder pressure, and decreases bladder compliance. To extensively explore its underlying mechanism, our study aimed to investigate the effect of pathological hydrostatic pressure on human bladder smooth muscle cell (hBSMC)

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