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Merck

A5282

Sigma-Aldrich

DL-2-氨基-5-膦酰戊酸

≥98% (TLC), solid, NMDA receptor antagonist

别名:

5-膦酰基-DL-正缬氨酸, DL-2-氨基-5-膦酰基缬草酸, AP-5, APV

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About This Item

经验公式(希尔记法):
C5H12NO5P
CAS号:
分子量:
197.13
Beilstein:
2446389
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.32

product name

DL-2-氨基-5-膦酰戊酸, solid

形狀

solid

顏色

white

溶解度

0.1 M NaOH: 4 mg/mL
H2O: 5.6 mg/mL
organic solvents: insoluble

SMILES 字串

NC(CCCP(O)(O)=O)C(O)=O

InChI

1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)

InChI 密鑰

VOROEQBFPPIACJ-UHFFFAOYSA-N

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應用

DL-2-氨基-5-膦酰戊酸已用于:
  • N-甲基-D-天冬氨酸(NMDA)介导突触灭活
  • 用于生长培养基用于抑制神经元网络的电活性
  • 用于分离N-甲基-D-天冬氨酸受体(NMDAR)或α-氨基-3-羟基-5-甲基-4-异噁唑丙酸受体(AMPAR)介导电流
  • 溶于双蒸水中,与朊蛋白(PrPC)比较其NMDA拮抗作用

生化/生理作用

镇痉;有效的选择性NMDA受体拮抗剂。

注意

吸湿

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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