所有图片(5)
About This Item
经验公式（希尔记法）:
C6H6N4
CAS号:
分子量:
134.14
Beilstein:
607843
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
product name
1-氨基苯并三唑,
化驗
≥98% (TLC)
品質等級
形狀
powder
環保替代產品評分
old score: 93
new score: 46
Find out more about DOZN™ Scoring
環保替代產品特色
Waste Prevention
Safer Solvents and Auxiliaries
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
mp
81-84 °C (lit.)
溶解度
ethanol: 49-51 mg/mL, clear, pale yellow to yellow
環保替代類別
SMILES 字串
Nn1nnc2ccccc12
InChI
1S/C6H6N4/c7-10-6-4-2-1-3-5(6)8-9-10/h1-4H,7H2
InChI 密鑰
JCXKHYLLVKZPKE-UHFFFAOYSA-N
基因資訊
human ... CYP1A2(1544)
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相关类别
一般說明
我们竭诚为您带来满足绿色替代产品四大类别要求的替代产品。本品属于重新设计产品类别，在绿色化学原理、“废物预防”、“溶剂和助剂安全性”以及“事故预防化学本安性”方面取得了关键改进。点击此处查看其 DOZN 记分卡。
應用
使用1-氨基苯并三唑作为细胞色素P450酶抑制剂，研究雌性激素对H2O2诱导的老年大鼠血管平滑肌细胞早衰的影响此外，它还被用于研究17β-雌二醇雌激素受体介导的效应。
生化／生理作用
1-氨基苯并三唑(1-ABT)在药物研究中用作体外工具。它能区分P450和非P450酶系统。1-ABT通过P450酶中血红素辅基的共价改变表现出抑制作用。
细胞色素 P450 和氯过氧化物酶的自杀抑制剂。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
J M Mathews et al.
The Journal of pharmacology and experimental therapeutics, 235(1), 186-190 (1985-10-01)
The autocatalytic destruction of pulmonary cytochrome P-450 (P-450) by 1-aminobenzotriazole (ABT) was investigated in microsomes and in isolated perfused lungs from untreated and beta-naphthoflavone-induced rabbits. Microsomal benzphetamine N-demethylase (BND) and 7-ethoxyresorufin O-deethylation (ERF) activities, catalyzed by P-450 isozymes 2 and
Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator?
Linder CD, et al.
Drug Metabolism and Disposition, 37(1), 10-13 (2009)
Effects of estrogen on stress-induced premature senescence of vascular smooth muscle cells: a novel mechanism for the ?time window theory? of menopausal hormone therapy
Zhu C, et al.
Atherosclerosis, 215(2), 294-300 (2011)
M Lizeth Orozco Morales et al.
iScience, 25(1), 103571-103571 (2022-01-06)
Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath. We compared cell lines injected either subcutaneously or intrapleurally and found that only the latter
Johan Bylund et al.
Journal of pharmaceutical sciences, 102(3), 1106-1115 (2013-01-15)
AZ'0908 is a novel microsomal prostaglandin E synthase-1 inhibitor intended for oral administration. Pharmacokinetic experiments in rats showed that bioavailability was much lower than anticipated and increased following pretreatment with the nonspecific cytochrome P450 (CYP) inhibitor 1-aminobenzotriazole, presumably by inhibition
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