化驗
≥98% (HPLC)
形狀
powder
顏色
white to off-white
溶解度
DMSO: >25 mg/mL
儲存溫度
2-8°C
SMILES 字串
Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(cc3)C#CCCC#N)C(=O)NN4CCS(=O)(=O)CC4
InChI
1S/C26H23Cl2N5O3S/c1-18-24(26(34)31-32-13-15-37(35,36)16-14-32)30-33(23-11-10-21(27)17-22(23)28)25(18)20-8-6-19(7-9-20)5-3-2-4-12-29/h6-11,17H,2,4,13-16H2,1H3,(H,31,34)
InChI 密鑰
XBHQLFVDGLPBCK-UHFFFAOYSA-N
一般說明
AM6545 is a cannabinoid (CB1) receptor antagonist.
生化／生理作用
AM6545 helps in decreasing the development of albuminuria, inflammation and expression of markers of fibrosis. It also helps in the down-regulation of nephrin and podocin. It has the ability to repress the ingestion of food and food-reinforced behaviour.
AM6545 is a peripheral CB1 cannabinoid receptor antagonist and appetite suppressant.
特點和優勢
This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Jin Zhang et al.
Molecular medicine reports, 19(3), 1491-1500 (2018-12-21)
Increasing evidence suggests that the dysregulation of microRNAs (miRNAs) has an important role in the progression of human cancer, including ESCC. However, the exact functions and mechanisms of miRNAs in ESCC remain largely unclear. The aim of the present study
Reversal of albuminuria by combined AM6545 and perindopril therapy in experimental diabetic nephropathy
Barutta F, et al.
British Journal of Pharmacology, 175(23), 4371-4385 (2018)
The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior
Randall PA, et al.
Pharmacol. Biochem., 97(1), 179-184 (2010)
Donovan A Argueta et al.
Physiology & behavior, 171, 32-39 (2017-01-10)
The endocannabinoid system in the brain and periphery plays a major role in controlling food intake and energy balance. We reported that tasting dietary fats was met with increased levels of the endocannabinoids, 2-arachidonoyl-sn-glycerol (2-AG) and anandamide, in the rat
Michael Ameismeier et al.
Nature, 587(7835), 683-687 (2020-11-20)
Eukaryotic ribosomes consist of a small 40S and a large 60S subunit that are assembled in a highly coordinated manner. More than 200 factors ensure correct modification, processing and folding of ribosomal RNA and the timely incorporation of ribosomal proteins1,2.
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