推荐产品
等級
Hybri-Max™
品質等級
無菌
γ-irradiated
產品線
BioXtra
形狀
lyophilized powder
技術
cell culture | hybridoma: suitable
雜質
endotoxin, tested
抗生素活性譜
fungi
作用方式
enzyme | inhibits
儲存溫度
−20°C
SMILES 字串
N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O
InChI
1S/C5H7N3O4/c6-3(5(10)11)2-12-4(9)1-8-7/h1,3H,2,6H2,(H,10,11)/t3-/m0/s1
InChI 密鑰
MZZGOOYMKKIOOX-VKHMYHEASA-N
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一般說明
Chemical structure: amino acid derivatives
應用
For use in hybridoma cell culture applications as a myeloma selection agent. Used to study inhibition of formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase.
生化／生理作用
Azaserine is an antibiotic, generated by Streptomyces fragilis. It is considered as a potential mutation inducing agent. It is known to promote pancreatic cancer and induces adenoma and carcinoma in vivo and in vitro. Azaserine also stimulates kidney and liver tumors in rats.
重構
10mL 无菌细胞培养基可复原一小瓶本品。储备液足以制备 500mL 培养基。最终工作浓度：5.7μM 偶氮丝氨酸。
法律資訊
Hybri-Max is a trademark of Sigma-Aldrich Co. LLC
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - Carc. 2
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
The Pathobiology of Neoplasia, 154-154 (2012)
Antineoplastic and Immunosuppressive Agents, Part 2, 494-494 (2013)
Tusty-Jiuan Hsieh et al.
The Journal of endocrinology, 183(3), 535-550 (2004-12-14)
We reported previously that insulin inhibits the stimulatory effect of high glucose on the expression of angiotensinogen (ANG) gene in both rat immortalized renal proximal tubular cells (IRPTCs) and non-diabetic rat renal proximal tubular cells (RPTCs), but has no effect
Angana Gupta Rajapakse et al.
American journal of physiology. Heart and circulatory physiology, 296(3), H815-H822 (2009-01-13)
Hexosamine biosynthetic pathway (HBP) accounts for some cardiovascular adverse effects of hyperglycemia. We investigated whether the HBP inhibitor azaserine protects against hyperglycemia-induced endothelial damage dependently of HBP. Human endothelial cells isolated from umbilical veins were exposed either to a high
Céline Masclaux-Daubresse et al.
Plant physiology, 140(2), 444-456 (2006-01-13)
Glutamate (Glu) metabolism and amino acid translocation were investigated in the young and old leaves of tobacco (Nicotiana tabacum L. cv Xanthi) using [15N]ammonium and [2-15N]Glu tracers. Regardless of leaf age, [15N]ammonium assimilation occurred via glutamine synthetase (GS; EC 6.1.1.3)
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