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化驗
≥98% (titration)
形狀
powder
反應適用性
reagent type: cross-linking reagent
mp
180-182 °C (lit.)
溶解度
H2O: 100 mg/mL
儲存溫度
−20°C
SMILES 字串
NNC(=O)CCCCC(=O)NN
InChI
1S/C6H14N4O2/c7-9-5(11)3-1-2-4-6(12)10-8/h1-4,7-8H2,(H,9,11)(H,10,12)
InChI 密鑰
IBVAQQYNSHJXBV-UHFFFAOYSA-N
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一般說明
己二酸二酰肼是一种同型双功能交联剂，对醛具有特异性。因而腙键相对稳定。在高碘酸盐氧化后，己二酸二酰肼常用于位点特异性连接各类糖蛋白，如抗体。低pKa的酰肼可避免与伯胺竞争，因此可在pH 5.0条件下进行氧化和偶联。
應用
己二酸二酰肼已用于：
- 制备反应性预混物，合成多孔生物材料
- 交联甲基丙烯酸化硫酸软骨素 (MA-CS) 涂层，利用基于碳二亚胺的化学方法生产和表征甲基丙烯酸化硫酸软骨素磁性纳米粒子(MA-CS MNPs)
- 使用Abberior STARNHS酯染料共价标记鼠李糖脂、绿脓杆菌素和万古霉素
生化／生理作用
己二酸二酰肼(ADH)是一种低分子量化合物，每个末端都包含一个酰肼基团。这可为重金属提供额外的吸附位点，从而维持或提高交联吸附剂的吸附能力。ADH可用作多个领域的交联剂，如制造机械乳胶膜和可注射氧化透明质酸水凝胶。
其他說明
请注意联氨键可以通过选择性还原来稳定，例如使用氰化钠。
危險聲明
危險分類
Aquatic Chronic 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
302.0 °F - closed cup
閃點（°C）
150 °C - closed cup
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
U Heimgartner et al.
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