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Sigma-Aldrich

钙黄绿素-AM

Small Package (20 X 50 μg ), ≥90.0% (HPLC)

别名:

荧光素氨羧络合试剂, 钙黄绿素四乙酰氧基 O,O′-二乙酸酯, Calcein O,O′-diacetate tetrakis(acetoxymethyl) ester

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About This Item

经验公式（希尔记法）:
C46H46N2O23
CAS号:
148504-34-1
分子量:
994.86
MDL號碼:
MFCD05861516
分類程式碼代碼:
12171500
PubChem物質ID:
329758218
NACRES:
NA.32

品質等級

100

化驗

≥90.0% (HPLC)

螢光

λex 496 nm; λem 516 nm±5 nm in 0.1 M Tris pH 8.0, esterase; Ca2+

儲存溫度

−20°C

SMILES 字串

CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)Cc1c(OC(C)=O)ccc2c1Oc3c(CN(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)c(OC(C)=O)ccc3C24OC(=O)c5ccccc45

InChI

1S/C46H46N2O23/c1-25(49)60-21-64-39(55)17-47(18-40(56)65-22-61-26(2)50)15-32-37(68-29(5)53)13-11-35-43(32)70-44-33(16-48(19-41(57)66-23-62-27(3)51)20-42(58)67-24-63-28(4)52)38(69-30(6)54)14-12-36(44)46(35)34-10-8-7-9-31(34)45(59)71-46/h7-14H,15-24H2,1-6H3

InChI 密鑰

XKFSBWQWNMZWFA-UHFFFAOYSA-N

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一般說明

钙黄绿素-AM，也称钙黄绿素-乙酰甲酯，是一种不发射荧光的分子，在细胞内酯酶的作用下会转化为阴离子荧光形式。在实验过程中它可以使黏附细胞连续成像。 钙黄绿素-AM是一种必不可少的染料，可在保持细胞膜完整的情况下将钙黄绿素引入活细胞。 钙黄绿素-AM中发射荧光的部分位于细胞间隙，在以酯酶依赖型关系在细胞中捕获，之后显示出细胞中的细胞毒性活性。

應用

钙黄绿素-AM是一种细胞活力染料，也可作为多药外排性转运体（multidrug efflux transporter）的中性底物。在癌症研究中，它可用作多药耐药蛋白MRP的中性底物。 用于测定人红细胞活力和老化的荧光测试法是以钙黄绿素-AM为探针。
钙黄绿素的非荧光细胞渗透衍生物，水解后发出荧光。 用作多药耐药蛋白MRP的中性底物；用于肿瘤研究。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCH5457
BCCG9095
BCCD6943
BCCC2661
BCBZ9720

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