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About This Item
经验公式（希尔记法）:
C44H47N3O24
CAS号:
分子量:
1001.85
Beilstein:
8183748
MDL號碼:
分類程式碼代碼:
12171500
PubChem物質ID:
NACRES:
NA.32
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產品線
BioReagent
品質等級
化驗
≥95.0% (HPLC)
形狀
solid
溶解度
DMSO: soluble
螢光
λex 355 nm; λem 495 nm in 0.1 M Tris pH 8.0, esterase; 10 mM Ca2+
適合性
suitable for fluorescence
儲存溫度
−20°C
SMILES 字串
CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)c1ccc(C)cc1OCCOc2cc3cc(oc3cc2N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)-c4ncc(o4)C(=O)OCOC(C)=O
InChI
1S/C44H47N3O24/c1-25-7-8-32(46(16-39(53)65-20-60-26(2)48)17-40(54)66-21-61-27(3)49)35(11-25)58-9-10-59-36-12-31-13-37(43-45-15-38(71-43)44(57)69-24-64-30(6)52)70-34(31)14-33(36)47(18-41(55)67-22-62-28(4)50)19-42(56)68-23-63-29(5)51/h7-8,11-15H,9-10,16-24H2,1-6H3
InChI 密鑰
VPSRLGDRGCKUTK-UHFFFAOYSA-N
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一般說明
Fura 2- am（Fura 2），又称乙酰氧基甲酯，是一种钙特定比率荧光染料。为了响应钙离子，像Fura 2这样的比例度量染料改变了各自的激发或发射光谱。细胞内钙浓度由不同波长的荧光发射比或激发决定。Fura 2的发射峰在505nm，激发峰在340-380nm之间，是首选的钙指示剂。
應用
Fura 2-AM是一种常用的探针，用于测定完整活细胞中细胞质游离钙的动态变化。
特點和優勢
使用Fura 2的酯形式作为Fura 2-AM的主要好处有：
- 可渗透细胞。
- 容易载入细胞中。
- 染料浓度。
- 照明强度、
- 光程长度。
其他說明
Fura-2的膜渗透性衍生物。用于将螯合剂渗透到细胞中。在细胞中发生酶促水解，产生Fura-2并保留在细胞内
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
M Poenie et al.
Nature, 315(6015), 147-149 (1985-05-09)
Although the regulation of events in the cell division cycle by calcium or other cations has been the subject of much interest and speculation, experimental studies have been hampered by the difficulty of measuring submicromolar intracellular free calcium concentrations ([Ca2+]i)
The use of microinjection and video microscopy for the study of calmodulin and calcium in living cells.
M Shelanski et al.
Methods in enzymology, 139, 824-834 (1987-01-01)
W Almers et al.
FEBS letters, 192(1), 13-18 (1985-11-11)
The Ca concentration ([Ca2+]i) in single rat peritoneal mast cells was measured by means of the new fluorescent Ca-indicator dye fura-2. Dye-loaded cells were made to degranulate with either antigen or compound 48/80. In cells loaded with extracellularly applied, membrane-permeant
Robin R Hodges et al.
Experimental eye research, 103, 99-113 (2012-09-15)
The purpose of this study was to identify the signaling pathways that epidermal growth factor (EGF) uses to stimulate mucin secretion from cultured rat conjunctival goblet cells and to compare the pathways used by EGF with those used by the
G Grynkiewicz et al.
The Journal of biological chemistry, 260(6), 3440-3450 (1985-03-25)
A new family of highly fluorescent indicators has been synthesized for biochemical studies of the physiological role of cytosolic free Ca2+. The compounds combine an 8-coordinate tetracarboxylate chelating site with stilbene chromophores. Incorporation of the ethylenic linkage of the stilbene
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