推荐产品
生物源
rabbit
品質等級
100
500
共軛
unconjugated
抗體表格
Ig fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
形狀
buffered aqueous solution
物種活性
human
包裝
vial of 0.1 mL concentrate (404A-14)
vial of 0.5 mL concentrate (404A-15)
bottle of 1.0 mL predilute (404A-17)
vial of 1.0 mL concentrate (404A-16)
bottle of 7.0 mL predilute (404A-18)
製造商／商標名
Cell Marque™
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
控制
lymph node, tonsil
運輸包裝
wet ice
儲存溫度
2-8°C
視覺化
cytoplasmic, membranous
基因資訊
human ... C4B(721)
一般說明
C4d is a stable split product remnant of classical complement activation which becomes covalently bound to endothelium and basement membrane, after induction of the classical antibody-induced pathway. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in both chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival and is an aid in treating acute rejection.
品質
 IVD |  IVD |  IVD |  RUO |
聯結
C4d Positive Control Slides, Product No. 404S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外觀
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
準備報告
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他說明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律資訊
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Dorothée Bouron-Dal Soglio et al.
Human pathology, 39(7), 1103-1110 (2008-06-24)
C4d is a marker of the activated complement cascade used to assess the humoral component of rejection, mostly in kidney allograft transplants. The role of C4d deposition has recently been addressed in hepatic allograft but has never been tested in
Gyongyi M Nadasdy et al.
Human pathology, 36(11), 1178-1185 (2005-11-02)
Detection of peritubular capillary (PTC) C4d deposition in tissue sections of renal allograft biopsies became an important aid in the diagnosis of antibody-mediated rejection. Pathologists in many major transplant centers now routinely stain renal allograft biopsies for C4d. Currently, there
Christian A Seemayer et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 22(2), 568-576 (2006-12-14)
Detection of C4d along peritubular capillaries (PTC) in renal allograft biopsies is an independent prognostic marker of poor long-term graft survival. It is typically associated with circulating donor-specific antibodies. Since only little information is available on the best technique to
Chen Jianghua et al.
Clinical transplantation, 19(6), 785-791 (2005-11-30)
To determine the diagnostic and clinical significance of C4d accumulation in renal allografts followed by acute rejection. A total of 158 graft biopsies performed from December 1997 to December 2002 were classified, according to the Banff-97 criteria, into hyperacute rejection
Prabhat Ranjan et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 23(5), 1735-1741 (2007-12-11)
Renal biopsy is the gold standard for diagnosis of acute rejection in renal transplant recipients. The Banff (1997) classification was revised in 2003 incorporating morphological criteria and C4d immunostaining for the diagnosis of acute antibody-mediated rejection. The aim of this
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