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Merck

37343

Sigma-Aldrich

7,8-Dihydroneopterin

≥97.0% (HPLC)

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About This Item

经验公式(希尔记法):
C9H13N5O4
CAS号:
分子量:
255.23
Beilstein:
1133875
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.25

品質等級

化驗

≥97.0% (HPLC)

形狀

solid

儲存溫度

−20°C

SMILES 字串

NC1=NC(=O)C2=C(NCC(=N2)[C@H](O)[C@H](O)CO)N1

InChI

1S/C9H13N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h4,6,15-17H,1-2H2,(H4,10,11,13,14,18)/t4-,6+/m1/s1

InChI 密鑰

YQIFAMYNGGOTFB-XINAWCOVSA-N

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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Barbara Wirleitner et al.
Clinical immunology (Orlando, Fla.), 107(3), 152-159 (2003-06-14)
Neopterin (Neo) and 7,8-dihydroneopterin (H(2)Neo) are produced by human monocyte-derived macrophages upon stimulation with IFN-gamma. Increased amounts of Neo and H(2)Neo in human body fluids are found in many disorders, including viral infections and autoimmune diseases. Recent data suggest that
Sarah K Baird et al.
Biochimica et biophysica acta, 1745(3), 361-369 (2005-08-09)
The atherosclerotic plaque is an inflammatory site where macrophage cells are exposed to cytotoxic oxidised low density lipoprotein (oxLDL). Interferon-gamma released from T-cells results in macrophage synthesis of 7,8-dihydroneopterin which has antioxidant and cytoprotective activity. Using the human derived monocyte-like
Sean Duggan et al.
Biochimica et biophysica acta, 1591(1-3), 139-145 (2002-08-17)
Monocyte cells are exposed to a range of reactive oxygen species (ROS) when they are recruited to a site of inflammation. In this study, we have examined the damage caused to the monocyte-like cell line U937 by peroxyl radicals and
Elizabeth A Flavall et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 863(1), 167-171 (2008-02-01)
Measurement of plasma neopterin by HPLC with fluorescence detection is used clinically as a marker of immune cell activation in the management of a number of disease pathologies. HPLC analysis of neopterin requires the acidic removal of plasma proteins but
Zahra Mashhadi et al.
Biochemistry, 48(40), 9384-9392 (2009-09-15)
7,8-Dihydro-D-neopterin 2',3'-cyclic phosphate (H(2)N-cP) is the first intermediate in biosynthesis of the pterin portion of tetrahydromethanopterin (H(4)MPT), a C(1) carrier coenzyme first identified in the methanogenic archaea. This intermediate is produced from GTP by MptA (MJ0775 gene product), a new

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