360376

辣椒素

63.7% (HPLC), powder, TRPV1 agonist

• 别名: 8-甲基-N-香草基-反-6-壬烯胺
• 线性分子式: (CH₃)₂CHCH=CH(CH₂)₄CONHCH₂C₆H₃-4-(OH)-3-(OCH₃)
• CAS号: 404-86-4
• 分子量: 305.41
• Beilstein: 2816484
• EC號碼: 206-969-8
• MDL號碼: MFCD00017259
• 分類程式碼代碼: 12352200
• PubChem物質ID: 57649462
• NACRES: NA.77

属性

• 产品名称: 辣椒素, natural
• 等級: natural
• 品質等級: 100
• 化驗: 63.7% (HPLC)
• 形狀: powder
• 成份: capsaicin, 65% ; dihydrocapsaicin, 35%
• mp: 62-65 °C (lit.)
• 溶解度: chloroform: 5%
• 儲存溫度: 2-8°C
• SMILES 字串: COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O
• InChI: 1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
• InChI 密鑰: YKPUWZUDDOIDPM-SOFGYWHQSA-N
• 基因資訊: human ... CYP1A2(1544) , TRPV1(7442) ; rat ... Trpv1(83810) , Trpv4(66026)

说明

一般說明

Capsaicin (Zostrix), an alkaloid extract is obtained from hot chili peppers. It is accessible in the form of cream and lotion. Capsaicin is a hydrophobic, instable and pungent white crystalline powder, that has no smell and color. It is produced by mixing a branched-chain fatty acid to vanillylamine in the chili pepper.

應用

Capsaicin has been used in the development of the isolation methods. It has also been used in the development of enzyme based electrochemical biosensor for the determination of capsaicin using a novel signal amplification strategy.

生化／生理作用

原型香草受体激动剂。 神经毒素；激活产生无髓C纤维的感觉神经元，其中许多含有P物质。 局部使用可使感觉神经末梢脱敏，从而产生反常的抗伤害感受作用；全身给药可对辣椒素敏感的细胞产生神经毒性，尤其是在新生动物中。辣椒的活性成分。

原型香草受体激动剂；神经毒素。辣椒的活性成分。

Capsaicin is used as an important component of oleoresin capsicum or pepper spray. It plays a beneficial role in obesity, cardiovascular and gastrointestinal conditions, several cancers, neurogenic bladder and dermatologic conditions. It is used in the production of spices, chilli sauces and pain-inducing defensive pepper sprays. Capsaicin is also used to manufacture creams to treat diabetic neuropathy, cluster headache, psoriasis, rheumatoid arthritis and reflex sympathetic dystrophy. It is considered as an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1).

安全信息

• 象形圖: GHS06,GHS08,GHS05
• 訊號詞: Danger
• 危險聲明: H300,H315,H317,H318,H334,H335
• 防範說明: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 2 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 235.4 °F - closed cup
• 閃點（°C）: 113 °C - closed cup
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges