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Merck

27029

Sigma-Aldrich

胆酸钠 水合物

≥97.0% (dried material, NT)

别名:

3α,7α,12α-三羟基-5β-胆甾烷-24-羧酸 钠盐, 胆酸 钠盐

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About This Item

经验公式(希尔记法):
C24H39NaO5 · xH2O
分子量:
430.55 (anhydrous basis)
Beilstein:
3582354
EC號碼:
MDL號碼:
分類程式碼代碼:
12161900
PubChem物質ID:
NACRES:
NA.25

描述

anionic

品質等級

化驗

≥97.0% (dried material, NT)

形狀

powder

光學活性

[α]20/D +36±2°, c = 0.6% in ethanol (dry matter)

分子量

micellar avg mol wt 900-1300

凝集数

2-3

損耗

≤5% loss on drying

CMC

9-15 mM (20-25°C)

溶解度

H2O: 0.1 M
H2O: 100 mg/mL

HLB

18

SMILES 字串

O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C

InChI

1S/C24H40O5.Na.H2O/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);;1H2/q;+1;/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;;/m1../s1

InChI 密鑰

MUVVIYFKOVLQHL-RCVKHMDESA-M

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一般說明

水合胆酸钠是一种生物表面活性剂,可作为水溶液中的还原剂。
水合胆酸钠是一种非变性阴离子洗涤剂。

應用


  • 经皮给药的优化:应用于超弹性纳米囊泡配方中的水合胆酸钠可提高地夫可特(deflazacort)的生物利用度和抗炎功效,展现了其在经皮给药系统中的潜力,可用于诊断目的(Ali et al., 2021)。

  • 用于IVD的纳米载体配方:该研究利用水合胆酸钠对胆汁体(bilosome)进行表面改性,其可作为杂化化合物的功能性和生物相容性纳米载体,该方法适用于创新IVD试剂的设计(Waglewska et al., 2020

  • 用于皮肤给药的体外诊断试剂配方:水合胆酸钠在用于递送抗氧化剂的纳米传递体开发中发挥了重要作用,研究显示了其在创造具有抗氧化和抗衰老作用的皮肤应用诊断试剂中的作用(Avadhani et al., 2017)。

  • 纳米技术中的分级和分离技术:水合胆酸钠显示了亲和力介导的分级顺序逆转(sorting order reversal)特性,它在密度梯度超速离心技术中至关重要,研究突显了其在诊断分析材料的精确分级和制备中的用途(Jang et al., 2016

危險聲明

防範說明

危險分類

Aquatic Chronic 3

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Ewelina Waglewska et al.
Nanomaterials (Basel, Switzerland), 10(12) (2020-12-17)
In the present contribution, we demonstrate a new approach for functionalization of colloidal nanomaterial consisting of phosphatidylcholine/cholesterol-based vesicular systems modified by FDA-approved biocompatible components, i.e., sodium cholate hydrate acting as a biosurfactant and Pluronic P123-a symmetric triblock copolymer comprising poly(ethylene
Sonia Biccai et al.
ACS nano, 13(6), 6845-6855 (2019-06-15)
Nanocomposite strain sensors, particularly those consisting of polymer-graphene composites, are increasingly common and are of great interest in the area of wearable sensors. In such sensors, application of strain yields an increase in resistance due to the effect of deformation
Jilite Wang et al.
Bioscience, biotechnology, and biochemistry, 79(3), 456-461 (2014-11-07)
Dietary plant protein is well known to reduce serum cholesterol levels. Rice bran is a by-product of rice milling and is a good source of protein. The present study examined whether feeding rats a high-cholesterol diet containing 10% rice bran
Mayu Kakehi et al.
Toxicological sciences : an official journal of the Society of Toxicology, 147(2), 360-369 (2015-07-17)
There are various interspecies differences in xenobiotic-metabolizing enzymes. It is known that cats show slow glucuronidation of drugs such as acetaminophen and strong side effects due to the UGT1A6 pseudogene. Recently, the UGT1A6 pseudogene was found in the Northern elephant
Yuri Kashima et al.
PloS one, 9(8), e105073-e105073 (2014-08-22)
Royal jelly (RJ) intake lowers serum cholesterol levels in animals and humans, but the active component in RJ that lowers serum cholesterol level and its molecular mechanism are unclear. In this study, we set out to identify the bile acid-binding

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