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Key Documents

255M-1

Sigma-Aldrich

Galectin-3 (9C4) Mouse Monoclonal Antibody

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

9C4, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (255M-14)
vial of 0.5 mL concentrate (255M-15)
bottle of 1.0 mL predilute (255M-17)
vial of 1.0 mL concentrate (255M-16)
bottle of 7.0 mL predilute (255M-18)

製造商/商標名

Cell Marque

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100

同型

IgG1

控制

papillary carcinoma of thyroid

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

cytoplasmic, nuclear

基因資訊

human ... LGALS3(3958)

一般說明

Galectin-3 is a 31 kD beta-galactosidase binding lectin. It has been associated with binding to the basement membrane glycoprotein laminin. Anti-Galectin-3 has been demonstrated to be valuable in differentiating between benign and malignant thyroid neoplasms in both histologic sections and fine needle aspiration biopsy material. Anti-Galectin-3 antibody has also been useful in identifying anaplastic large cell lymphoma.

品質


IVD

IVD

IVD

RUO

聯結

Galectin-3 Positive Control Slides, Product No. 255S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

準備報告

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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F Orlandi et al.
Cancer research, 58(14), 3015-3020 (1998-07-29)
Galectin-3 is a carbohydrate-binding protein endowed with an affinity for beta-galactosides. It has been shown to play an important role in cell-cell and cell-matrix interactions and in pre-mRNA splicing. Furthermore, it is involved in the control of cell growth, neoplastic
Mauro Papotti et al.
European journal of endocrinology, 147(4), 515-521 (2002-10-09)
Cystic thyroid lesions can harbour an occult papillary carcinoma, which fine needle aspiration (FNA) biopsy may fail to detect. Recently, new markers such as galectin-3 lectin have been proposed to distinguish benign from malignant thyroid lesions of follicular origin. The
Marille E Herrmann et al.
Archives of pathology & laboratory medicine, 126(6), 710-713 (2002-05-30)
The expression of galectin-3, a human lectin, has been shown to be highly associated with malignant behavior of thyroid lesions. We studied the immunohistochemical expression pattern of galectin-3 in a variety of follicular-derived thyroid lesions (13 benign and 62 malignant)
A Gasbarri et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 17(11), 3494-3502 (1999-11-05)
Thyroid cancer is the most frequently occurring endocrine malignancy; however, preoperative diagnosis of some lesions, in particular those with follicular histology, is difficult, and a consistent number of not otherwise-specified "follicular nodules" are surgically resected more for diagnosis than therapeutic
A Bartolazzi et al.
Lancet (London, England), 357(9269), 1644-1650 (2001-06-27)
Thyroid cancer is the most common endocrine malignant disease, but preoperative diagnosis remains a challenge. Fine-needle aspiration cytology has greatly improved the clinical management of thyroid nodules, but the preoperative characterisation of follicular lesions is very difficult. Many patients are

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