推荐产品
生物源
mouse
品質等級
100
500
共軛
unconjugated
抗體表格
diluted ascites fluid
抗體產品種類
primary antibodies
無性繁殖
MRQ-10, monoclonal
描述
For In Vitro Diagnostic Use in Select Regions (See Chart)
形狀
buffered aqueous solution
物種活性
human
包裝
vial of 0.1 mL concentrate (309M-14)
vial of 0.5 mL concentrate (309M-15)
bottle of 1.0 mL predilute (309M-17)
vial of 1.0 mL concentrate (309M-16)
bottle of 7.0 mL predilute (309M-18)
製造商／商標名
Cell Marque™
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
同型
IgG
控制
seminoma
運輸包裝
wet ice
儲存溫度
2-8°C
視覺化
nuclear
基因資訊
human ... POU5F1(5460)
一般說明
Oct-4 is a transcription factor that functions in the regulation and maintenance of pluripotency in embryonic stem and primordial germ cells. Oct-4 immunoreactivity has been demonstrated in gonadal and extra-gonadal seminomas, dysgerminomas, and embryonal carcinomas. In addition, the immunohistochemical detection of Oct-4 assists in the evaluation of intratubular germ cell neoplasia (IGCN).
Oct-4 is a transcription factor that maintains and regulates pluripotency in embryonic stem and germ cells. Anti-Oct-4 has shown a very high sensitivity and specificity in seminoma/dysgerminoma, embryonal carcinoma, and the germ cell component of gonadoblastoma by nuclear immunostaining. Clear cell carcinoma may enter the differential diagnosis of dysgerminoma as both may grow in nests or tubules, contain clear cells, and have a prominent inflammatory infiltrate (lymphocytes in dysgerminoma and plasma cells in clear cell carcinoma). In one study that looked at anti-Oct-4 staining in clear cell carcinomas, 4 of 14 tumors were found to be focally positive. In another study, 49 endometrioid carcinomas were Oct-4 negative. Rarely dysgerminoma may have a morphologic appearance that overlaps with sex cord-stromal tumors, especially poorly differentiated Sertoli cell tumors. In two studies however, all sex cord-stromal tumors of the testis and granulosa cell tumors of the ovary were Oct-4 negative.
品質
 IVD |  IVD |  IVD |  RUO |
聯結
Oct-4 Positive Control Slides, Product No. 309S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外觀
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
準備報告
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
其他說明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律資訊
Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Patricia M Baker et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 24(1), 39-55 (2005-01-01)
Immunohistochemistry has become an important tool in the diagnosis of ovarian tumors. This article reviews the role of immunohistochemistry in the differential diagnosis of the three main categories of ovarian tumors, with emphasis on recently developed antibodies. In the surface
K Biermann et al.
Histopathology, 49(3), 290-297 (2006-08-22)
To compare the suitability of new seminoma markers including transcription factors AP-2gamma, OCT3/4 and M2A for detection of metastatic and extragonadal seminomas with the two well-known markers c-KIT and PLAP. The immunohistochemical distribution of PLAP, c-KIT, M2A, AP-2gamma and OCT3/4
Martine Cools et al.
The Journal of clinical endocrinology and metabolism, 91(6), 2404-2413 (2006-04-13)
The purpose of the study was to define the histological origin of gonadoblastomas, allowing the identification of high-risk patients. Sixty paraffin-embedded gonadectomy or gonadal biopsy samples of 43 patients with gonadal dysgenesis were selected from our archives. We studied the
Chien-Jui Cheng et al.
Journal of biomedical science, 14(6), 797-807 (2007-08-09)
Testicular germ cell tumors (TGCTs), comprised of seminomas and non-seminomas, are derived from premalignant and noninvasive intracellular germ cell neoplasias. Among TGCTs, seminomas are believed to resemble a transformed state of primordial germ cells (PGCs) and are known to exhibit
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