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品質等級
化驗
≥95.0% (HPLC)
應用
metabolomics
vitamins, nutraceuticals, and natural products
SMILES 字串
COc1cc(ccc1O)C2=C(O)C(=O)c3c(O)cc(O)cc3O2
InChI
1S/C16H12O7/c1-22-11-4-7(2-3-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3
InChI 密鑰
IZQSVPBOUDKVDZ-UHFFFAOYSA-N
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一般說明
异鼠李素是一种 O-甲基化黄酮醇，存在于水果、植物和草药中。它是槲皮素的代谢物。
應用
异鼠李素（IRN）可用于：
- 作为神经保护剂，以研究东莨菪碱所致小鼠皮质-海马学习和记忆障碍的影响
- 作为四极杆飞行时间串联质谱法（QTOF MS）的参考标准，以分析并量化蜂蜜提取物中的酚类化合物
- 作为参考标准品，通过反相高效液相色谱法及二极管阵列检测和电喷雾质谱法（RP-HPLC-DAD-ESI-TQ-MS/MS）测定蒿属酚的含量
生化／生理作用
异鼠李素具有抗氧化、抗炎症、抗肿瘤、抗菌和抗病毒的作用。作为一种潜在的神经保护剂，可抑制糖尿病（DM）患者海马结构的神经退行性变。低水平的异鼠李素可以作为一种抗糖尿病药物，促进骨骼肌细胞对葡萄糖的摄取并在高血糖情况下维持血糖稳态。它调节了核因子 kB（NF-κB）、磷脂酰肌醇 3-激酶（PI3K）/蛋白激酶（AKT）、丝裂原活化蛋白激酶（MAPK）等细胞信号通路。异鼠李素对动脉粥样硬化和心血管疾病具有保护和治疗作用。
异鼠李素通过干扰脂肪干细胞的分化来抑制脂肪形成，其机制为稳定 β-连环蛋白和上调 Wnt 信号通路。
包裝
无底玻璃瓶。内含物在插入的融合锥体内。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
其他客户在看
Rongsheng E Wang et al.
Journal of medicinal chemistry, 52(7), 1912-1921 (2009-03-20)
Inhibitors of heat-induced heat shock protein 70 (HSP70) expression have the potential to enhance the therapeutic effectiveness of heat-induced radiosensitization of tumors. Among known small molecule inhibitors, quercetin has the advantage of being easily modified for structure-activity studies. Herein, we
Lutz Franke et al.
Journal of medicinal chemistry, 50(11), 2640-2646 (2007-04-28)
A natural product collection and natural-product-derived combinatorial libraries were virtually screened for potential inhibitors of human 5-lipoxygenase (5-LO) activity. We followed a sequential ligand-based approach in two steps. First, similarity searching with a topological pharmacophore descriptor (CATS 2D method) was
Gang Gong et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 128, 110301-110301 (2020-06-06)
Isorhamnetin is one of the most important active ingredients in the fruits of Hippophae rhamnoides L. and the leaves of Ginkgo biloba L., which possesses extensive pharmacological activities. At present, there have been numerous investigations on isorhamnetin, which has the
Ismail O Ishola et al.
Brain research, 1712, 188-196 (2019-02-18)
Isorhamnetin (IRN), a 3'-O-methylated metabolite of quercetin has antioxidant, anti-inflammatory and neuroprotective properties. In this study, we investigated the learning and memory enhancing effects of IRN on spatial and non-spatial learning and memory deficits induced by scopolamine (3 mg/kg, i.p; muscarinic
Mohamed Moalin et al.
Molecules (Basel, Switzerland), 16(11), 9636-9650 (2011-11-23)
The polyphenol quercetin (Q) that has a high antioxidant capacity is a lead compound in the design of antioxidants. We investigated the possibility of modifying quercetin while retaining its antioxidant capacity as much as possible. To this end, the antioxidant
商品
Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.
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