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Key Documents

135R-1

Sigma-Aldrich

CD35 (EP197) Rabbit Monoclonal Primary Antibody

别名:

C3-binding protein, C3BR, C3b/C4b receptor, C4BR, CD35 antigen, CR1, Complement Receptor 1, Complement component (3b/4b) receptor 1 (Knops blood group), Knops blood group antigen

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

EP197, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions (See Chart)

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (135R-14)
vial of 0.1 mL concentrate Research Use Only (135R-14-RUO)
vial of 0.5 mL concentrate (135R-15)
vial of 1.0 mL concentrate (135R-16)
vial of 1.0 mL concentrate Research Use Only (135R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (135R-17-RUO)
vial of 1.0 mL predilute ready-to-use (135R-17)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (135R-18-RUO)
vial of 7.0 mL predilute ready-to-use (135R-18)

製造商/商標名

Cell Marque

濃度

0.1-5.0 μg/mL (predilute)
2.5-125 μg/mL (concentrate)

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同型

IgG

控制

tonsil

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

membranous

基因資訊

human ... CR1(1378)

一般說明

CD35 (complement receptor 1) is a cell membrane-bound, monomeric glycoprotein found on numerous cell types including erythrocytes, leukocytes, glomerular podocytes, and follicular dendritic cells. The primary function of CD35 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. CD35 antigen is found on erythrocytes, B cells, a subset of T cells, monocytes, as well as eosinophils and neutrophils. Anti-CD35 is considered a mature B-cell marker which labels follicular dendritic reticulum cells and tumors derived from such cells such as follicular dendritic cell tumor/sarcoma.

品質

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

聯結

CD35 Positive Control Slides, Product No. 135S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

準備報告

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

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Inflammatory pseudotumor-like follicular dendritic cell tumor: a distinctive low-grade malignant intra-abdominal neoplasm with consistent Epstein-Barr virus association.
Cheuk W, Chan JK, Shek TW, et al.
American Journal of Surgical Pathology, 25(6), 721-731 (2001)
Mediastinal mixed dendritic cell sarcoma with hybrid features.
Dillon KM, Hill CM, Cameron CH, et al.
Journal of Clinical Pathology, 55(10), 791-794 (2002)
Germinal centre-like versus undifferentiated stromal immunophenotypes in follicular lymphoma.
Chang KC, Huang X, Medeiros LJ, et al.
The Journal of Pathology, 201(3), 404-412 (2003)
Extranodal follicular dendritic cell sarcoma of the head and neck region: three new cases, with a review of the literature.
Biddle DA, Ro JY, Yoon GS, et al.
Modern Pathology, 15(1), 50-58 (2002)
Immunohistochemical recognition of human follicular dendritic cell (FDCs) in routinely processed paraffin section.
Kunihikom, M., et al.
The Journal of Histochemistry and Cytochemistry, 50, 1475-1486 (2002)

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