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Merck

PHR1691

Supelco

4-差向脱水四环素 盐酸盐

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

(4R,4aS,12aS)-4-(二甲氨基)-1,4,4a,5,12,12a-六氢-3,10,11,12a-四羟基-6-甲基-1,12-二氧代-2-并四苯甲酰胺 单盐酸盐

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About This Item

经验公式(希尔记法):
C22H22N2O7 · HCl
CAS号:
分子量:
462.88
Beilstein:
3840711
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

certified reference material
pharmaceutical secondary standard

品質等級

agency

traceable to Ph. Eur. E0400000
traceable to USP 1236506

API 家族

chlortetracycline, tetracycline

CofA

current certificate can be downloaded

包裝

pkg of 500 mg

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

SMILES 字串

Cl[H].[H][C@@]12Cc3c(C)c4cccc(O)c4c(O)c3C(=O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H]2N(C)C

InChI

1S/C22H22N2O7.ClH/c1-8-9-5-4-6-12(25)13(9)17(26)14-10(8)7-11-16(24(2)3)18(27)15(21(23)30)20(29)22(11,31)19(14)28;/h4-6,11,16,25-27,31H,7H2,1-3H3,(H2,23,30);1H/t11-,16+,22-;/m0./s1

InChI 密鑰

XBSQEFHDCDFNJU-MOMXNFOMSA-N

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一般說明

4-Epianhydrotetracycline hydrochloride is a degradation product of tetracyclines which are used as veterinary medicines.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

應用

4-Epianhydrotetracycline hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in commercial bulk and pharmaceutical products by high performance liquid chromatography (HPLC).
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析報告

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

腳註

To see an example of a Certificate of Analysis for this material enter LRAA6863 in the slot below. This is an example certificate only and may not be the lot that you receive.

相關產品

产品编号
说明
价格

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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分析证书(COA)

Lot/Batch Number

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4-Epianhydrotetracycline
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 6636-6636 (2013)
A high performance liquid chromatographic system for the analysis of tetracycline drug standards, analogs, degradation products and other impurities
Mack GD and Ashworth RB
Journal of Chromatographic Science, 16(3), 93-101 (1978)
Emad M Hussien
Biomedical chromatography : BMC, 28(9), 1278-1283 (2014-03-13)
A novel reversed-phase HPLC method was developed and validated for the assay of tetracycline hydrochloride and the limit of 4-epianhydrotetracycline hydrochloride impurity in tetracycline hydrochloride commercial bulk and pharmaceutical products. The method employed L1 (3 µm, 150 × 4.6 mm) columns, a mobile phase

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