PHR1265

Carvedilol

Pharmaceutical Secondary Standard; Certified Reference Material

• 别名: 卡维地洛
• 经验公式（希尔记法）: C₂₄H₂₆N₂O₄
• CAS号: 72956-09-3
• 分子量: 406.47
• MDL號碼: MFCD00864692
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329823261
• NACRES: NA.24

属性

• 等級: certified reference material; pharmaceutical secondary standard
• 品質等級: 300
• agency: traceable to Ph. Eur. Y0001427; traceable to USP 1096622
• API 家族: carvedilol
• CofA: current certificate can be downloaded
• 技術: HPLC: suitable; gas chromatography (GC): suitable
• 應用: pharmaceutical (small molecule)
• 形式: neat
• 儲存溫度: 2-30°C
• SMILES 字串: OC(COC1=CC=CC2=C1C3=C(C=CC=C3)N2)CNCCOC4=CC=CC=C4OC
• InChI: 1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3
• InChI 密鑰: OGHNVEJMJSYVRP-UHFFFAOYSA-N
• 基因資訊: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRB1(153) , ADRB2(154) , ADRB3(155)

说明

一般說明

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Carvedilol is a lipophilic β₁- and β₂-adrenoreceptor antagonist that exhibits antioxidant and antiproliferative properties. It is prescribed as a medicine for the treatment of hypertension, stable angina pectoris, post myocardial infarction with left ventricular dysfunction and all degrees of symptomatic chronic heart failure.

應用

Carvedilol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and serum samples by various chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化／生理作用

Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity.

Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity. Carvedilol is used specifically for the treatment of heart failure and high blood pressure. It has been shown to improve left ventricular ejection fraction and may reduce mortality.

注意

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

分析報告

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

腳註

To see an example of a Certificate of Analysis for this material enter LRAA9063 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全信息

• 象形圖: GHS08,GHS09
• 訊號詞: Warning
• 危險聲明: H373,H411
• 防範說明: P260 - P273 - P314 - P391 - P501
• 危險分類: Aquatic Chronic 2 - STOT RE 2
• 標靶器官: Liver,spleen,Uterus (including cervix),Adrenal gland
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable